Rinaldi Francesca, Lissandrin Raffaella, Mojoli Francesco, Baldanti Fausto, Brunetti Enrico, Pascarella Michela, Giordani Maria Teresa
Department of Infectious Diseases, IRCCS San Matteo Hospital Foundation, University of Pavia, Viale Golgi 19, 27100 Pavia, Italy.
Clinical-Surgical, Diagnostic and Pediatric Sciences Department, Section of Anesthesia and Intensive Care 1, University of Pavia, IRCCS San Matteo Hospital Foundation, Viale Golgi 19, 27100 Pavia, Italy.
Mediterr J Hematol Infect Dis. 2014 Jun 1;6(1):e2014041. doi: 10.4084/MJHID.2014.041. eCollection 2014.
Acute Human Cytomegalovirus (HCMV) infection is an unusual cause of venous thromboembolism, a potentially life-threatening condition. Thrombus formation can occur at the onset of the disease or later during the recovery and may also occur in the absence of acute HCMV hepatitis. It is likely due to both vascular endothelium damage caused by HCMV and impairment of the clotting balance caused by the virus itself. Here we report on two immunocompetent women with splanchnic thrombosis that occurred during the course of acute HCMV infection. Although the prevalence of venous thrombosis in patients with acute HCMV infection is unknown, physicians should be aware of its occurrence, particularly in immunocompetent patients presenting with fever and unexplained abdominal pain.
急性人类巨细胞病毒（HCMV）感染是静脉血栓栓塞这种潜在危及生命状况的一种罕见病因。血栓形成可在疾病发作时或恢复后期出现，也可能在无急性HCMV肝炎的情况下发生。这可能是由于HCMV引起的血管内皮损伤以及病毒本身导致的凝血平衡受损。在此，我们报告两名免疫功能正常的女性，她们在急性HCMV感染过程中发生了内脏血栓形成。尽管急性HCMV感染患者中静脉血栓形成的患病率尚不清楚，但医生应意识到其发生，尤其是在出现发热和不明原因腹痛的免疫功能正常患者中。
