Department of Dermatology, The Saarland University Hospital, Homburg, Germany.
Adv Exp Med Biol. 2012;727:258-64. doi: 10.1007/978-1-4614-0899-4_19.
Increasing evidence indicates that Notch signaling contributes to physiologic processes, including development, differentiation and tumorigenesis, either as a tumor promoter or suppressor depending on the cellular context, level of expression and cross-talk with other signaling systems. Notch signalling has been implicated in the regulation of self-renewal of adult stem cells and differentiation of precursors along a specific cell line in normal embryonic development and organogenesis. There is also evidence that signaling through Notch receptors regulates cell proliferation and cell survival in several types of cancer including malignant melanoma, with opposing results depending on the tissue context. Tumor progression/metastasis of malignant melanoma are complicated processes that require multiple cellular events, including cell proliferation, survival, migration and invasion. Notch signaling appears to be a promising system for new therapeutic targets for the treatment of melanoma and perhaps the prevention of melanoma metastasis.
越来越多的证据表明，Notch 信号通路参与了生理过程，包括发育、分化和肿瘤发生，其作用是肿瘤促进剂还是抑制剂取决于细胞环境、表达水平以及与其他信号系统的相互作用。Notch 信号通路在调节成体干细胞的自我更新和正常胚胎发育和器官发生中沿着特定细胞谱系分化的前体细胞方面发挥作用。也有证据表明，Notch 受体信号通路通过调节几种类型的癌症（包括恶性黑色素瘤）中的细胞增殖和细胞存活来发挥作用，但其结果取决于组织环境。恶性黑色素瘤的肿瘤进展/转移是一个复杂的过程，需要多个细胞事件，包括细胞增殖、存活、迁移和侵袭。Notch 信号通路似乎是一个很有前途的治疗靶点系统，可用于治疗黑色素瘤，也许还可以预防黑色素瘤转移。
