• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

白细胞介素-1及白细胞介素-1受体拮抗剂在接受体外受精-胚胎移植的女性体外胚胎发育中的作用

Involvement of interleukin-1 and the interleukin-1 receptor antagonist in in vitro embryo development among women undergoing in vitro fertilization-embryo transfer.

作者信息

Spandorfer S D, Neuer A, Liu H C, Rosenwaks Z, Witkin S S

机构信息

The Center for Reproductive Medicine and Infertility, The New York Hospital/Cornell Medical Center, New York, New York 10021, USA.

出版信息

J Assist Reprod Genet. 2003 Dec;20(12):502-5. doi: 10.1023/b:jarg.0000013650.76052.ae.

DOI:10.1023/b:jarg.0000013650.76052.ae
PMID:15035549
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3455304/
Abstract

PURPOSE

To examine the roles of Interleukin-1 (IL-1) and IL-1 receptor antagonist (IL-1ra), in in vitro embryo development and subsequent pregnancy outcome.

METHODS

Maternal serum utilized to supplement embryo growth in IVF cycles was analyzed for the presence of IL-1 cytokines.

RESULTS

The maternal serum that was utilized to supplement the embryo media was found to have measurable amounts of IL-1beta and IL-1ra.

CONCLUSIONS

Relative antagonism of the IL-1 system was positively associated with embryo development and pregnancy outcome.

摘要

目的

研究白细胞介素-1（IL-1）和IL-1受体拮抗剂（IL-1ra）在体外胚胎发育及随后妊娠结局中的作用。

方法

分析用于补充体外受精周期中胚胎生长的母体血清中IL-1细胞因子的存在情况。

结果

发现用于补充胚胎培养基的母体血清中含有可测量的IL-1β和IL-1ra。

结论

IL-1系统的相对拮抗作用与胚胎发育和妊娠结局呈正相关。

相似文献

1
Involvement of interleukin-1 and the interleukin-1 receptor antagonist in in vitro embryo development among women undergoing in vitro fertilization-embryo transfer.白细胞介素-1及白细胞介素-1受体拮抗剂在接受体外受精-胚胎移植的女性体外胚胎发育中的作用
J Assist Reprod Genet. 2003 Dec;20(12):502-5. doi: 10.1023/b:jarg.0000013650.76052.ae.
2
Interleukin-1 levels in the supernatant of conditioned media of embryos grown in autologous endometrial coculture: correlation with outcome after in vitro fertilization.
Am J Reprod Immunol. 2000 Jan;43(1):6-11. doi: 10.1111/j.8755-8920.2000.430102.x.
3
Elevated serum interleukin-1β levels and interleukin-1β-to-interleukin-1 receptor antagonist ratio 1 week after embryo transfer are associated with ectopic pregnancy.胚胎移植后1周血清白细胞介素-1β水平升高以及白细胞介素-1β与白细胞介素-1受体拮抗剂的比值升高与异位妊娠有关。
Fertil Steril. 2015 Nov;104(5):1190-4. doi: 10.1016/j.fertnstert.2015.07.1145. Epub 2015 Aug 14.
4
IL-1β predicts IVF outcome: a prospective study.IL-1β 预测 IVF 结局：一项前瞻性研究。
J Assist Reprod Genet. 2018 Nov;35(11):2031-2035. doi: 10.1007/s10815-018-1296-0. Epub 2018 Sep 17.
5
Good fertilization results associated with high IL-1beta concentrations in follicular fluid of IVF patients.体外受精患者卵泡液中白细胞介素-1β浓度高与良好的受精结果相关。
J Reprod Med. 2013 Nov-Dec;58(11-12):485-90.
6
Hormonal regulation of serum and endometrial IL-1 alpha, IL-1 beta and IL-1ra: IL-1 endometrial microenvironment of the human embryo at the apposition phase under physiological and supraphysiological steroid level conditions.血清和子宫内膜白细胞介素-1α、白细胞介素-1β及白细胞介素-1受体拮抗剂的激素调节：生理和超生理类固醇水平条件下人类胚胎着床期子宫内膜白细胞介素-1的微环境
J Reprod Immunol. 1996 Oct;31(3):165-84. doi: 10.1016/0165-0378(96)00982-5.
7
Expression of interleukin-1 system mRNA in single blastomeres from human preimplantation embryos.人植入前胚胎单个卵裂球中白细胞介素-1系统mRNA的表达
Hum Reprod. 1998 Aug;13(8):2206-11. doi: 10.1093/humrep/13.8.2206.
8
Interleukin-1 beta levels in human embryo culture supernatants and their predictive value for pregnancy.
Early Hum Dev. 1997 Apr 25;48(1-2):71-80. doi: 10.1016/s0378-3782(96)01837-3.
9
Prediction of successful embryo implantation by measuring interleukin-1-alpha and immunosuppressive factor(s) in preimplantation embryo culture fluid.
Fertil Steril. 1991 May;55(5):952-7. doi: 10.1016/s0015-0282(16)54305-2.
10
Lack of association with interleukin 1 receptor antagonist and interleukin-1beta gene polymorphisms in sarcoidosis patients.结节病患者中白细胞介素-1受体拮抗剂及白细胞介素-1β基因多态性的相关性缺失
Respir Med. 2000 Nov;94(11):1038-42. doi: 10.1053/rmed.2000.0892.

引用本文的文献

1
Oviductal extracellular matrix hydrogels enhance in vitro culture of rabbit embryos and reduce deficiencies during assisted reproductive technologies.输卵管细胞外基质水凝胶可提高兔胚胎体外培养效率，并减少辅助生殖技术过程中的胚胎缺陷。
Sci Rep. 2024 Nov 11;14(1):27579. doi: 10.1038/s41598-024-77583-4.
2
Interleukin-1β induces and accelerates human endometrial stromal cell senescence and impairs decidualization via the c-Jun N-terminal kinase pathway.白细胞介素-1β通过c-Jun氨基末端激酶途径诱导并加速人子宫内膜基质细胞衰老，损害蜕膜化过程。
Cell Death Discov. 2024 Jun 15;10(1):288. doi: 10.1038/s41420-024-02048-6.
3
Detection of Interleukin-1 β (IL-1β) in Single Human Blastocyst-Conditioned Medium Using Ultrasensitive Bead-Based Digital Microfluidic Chip and Its Relationship with Embryonic Implantation Potential.使用超灵敏基于珠的数字微流控芯片检测单个人类囊胚条件培养基中的白细胞介素-1β（IL-1β）及其与胚胎着床潜能的关系。
Int J Mol Sci. 2024 Apr 3;25(7):4006. doi: 10.3390/ijms25074006.
4
Serum Cu, Zn and IL-1β Levels May Predict Fetal Miscarriage Risk After IVF Cycles: A Nested Case-Control Study.血清铜、锌和白细胞介素-1β水平可能预测 IVF 周期后胎儿流产的风险：一项巢式病例对照研究。
Biol Trace Elem Res. 2023 Dec;201(12):5561-5574. doi: 10.1007/s12011-023-03621-3. Epub 2023 Mar 25.
5
The Update Immune-Regulatory Role of Pro- and Anti-Inflammatory Cytokines in Recurrent Pregnancy Losses.探讨促炎和抗炎细胞因子在复发性妊娠丢失中的免疫调节作用的更新。
Int J Mol Sci. 2022 Dec 21;24(1):132. doi: 10.3390/ijms24010132.
6
Early Mid-pregnancy Blood-Based Proteins as Possible Biomarkers of Increased Infant Birth Size in Sex-Stratified Analyses.早孕期血基蛋白作为性别分层分析中增加婴儿出生体重的潜在生物标志物。
Reprod Sci. 2023 Apr;30(4):1165-1175. doi: 10.1007/s43032-022-01093-9. Epub 2022 Sep 30.
7
Pro- and Anti-Inflammatory Cytokines in the First Trimester-Comparison of Missed Miscarriage and Normal Pregnancy.早孕期促炎及抗炎细胞因子的变化：稽留流产与正常妊娠的比较。
Int J Environ Res Public Health. 2021 Aug 12;18(16):8538. doi: 10.3390/ijerph18168538.
8
Cabergoline Stimulates Human Endometrial Stromal Cell Decidualization and Reverses Effects of Interleukin-1β In Vitro.卡麦角林体外刺激人子宫内膜基质细胞蜕膜化并逆转白细胞介素-1β的作用。
J Clin Endocrinol Metab. 2021 Nov 19;106(12):3591-3604. doi: 10.1210/clinem/dgab511.
9
Human Endometrial Stromal Cell Differentiation is Stimulated by PPARβ/δ Activation: New Targets for Infertility?人子宫内膜基质细胞的分化受过氧化物酶体增殖物激活受体β/δ的刺激：不孕的新靶点？
J Clin Endocrinol Metab. 2020 Sep 1;105(9):2983-95. doi: 10.1210/clinem/dgaa413.
10
Cytokines in relation to hCG are significantly altered in asymptomatic women with miscarriage - a pilot study.无症状流产妇女的细胞因子与 hCG 相关显著改变——一项初步研究。
Reprod Biol Endocrinol. 2018 Sep 28;16(1):93. doi: 10.1186/s12958-018-0411-5.

本文引用的文献

1
Interleukin-1 levels in the supernatant of conditioned media of embryos grown in autologous endometrial coculture: correlation with outcome after in vitro fertilization.
Am J Reprod Immunol. 2000 Jan;43(1):6-11. doi: 10.1111/j.8755-8920.2000.430102.x.
2
Culture and selection of viable blastocysts: a feasible proposition for human IVF?活胚泡的培养与选择：人类体外受精的可行方案？
Hum Reprod Update. 1997 Jul-Aug;3(4):367-82. doi: 10.1093/humupd/3.4.367.
3
Role of endometrial factors in regulating secretion of components of the immunoreactive human embryonic interleukin-1 system during embryonic development.子宫内膜因子在胚胎发育过程中调节免疫反应性人胚胎白细胞介素-1系统成分分泌中的作用。
Biol Reprod. 1996 Mar;54(3):563-74. doi: 10.1095/biolreprod54.3.563.
4
Embryonic implantation in mice is blocked by interleukin-1 receptor antagonist.白细胞介素-1受体拮抗剂可阻断小鼠胚胎着床。
Endocrinology. 1994 Feb;134(2):521-8. doi: 10.1210/endo.134.2.8299552.
5
Assisted hatching facilitates earlier implantation.辅助孵化有助于更早着床。
Fertil Steril. 1993 Nov;60(5):871-5.
6
Interleukin-1 system in the materno-trophoblast unit in human implantation: immunohistochemical evidence for autocrine/paracrine function.人着床过程中母-滋养层细胞单元中的白细胞介素-1系统：自分泌/旁分泌功能的免疫组织化学证据
J Clin Endocrinol Metab. 1994 Apr;78(4):847-54. doi: 10.1210/jcem.78.4.8157710.
7
Interleukin-1 beta, human leukocyte antigen HLA-DR alpha, and transforming growth factor-beta expression in endometrium, placenta, and placental membranes.白细胞介素-1β、人类白细胞抗原HLA-DRα以及转化生长因子-β在子宫内膜、胎盘和胎膜中的表达
Am J Obstet Gynecol. 1990 Nov;163(5 Pt 1):1430-7. doi: 10.1016/0002-9378(90)90601-3.