白细胞介素-1及白细胞介素-1受体拮抗剂在接受体外受精-胚胎移植的女性体外胚胎发育中的作用
Involvement of interleukin-1 and the interleukin-1 receptor antagonist in in vitro embryo development among women undergoing in vitro fertilization-embryo transfer.
作者信息
Spandorfer S D, Neuer A, Liu H C, Rosenwaks Z, Witkin S S
机构信息
The Center for Reproductive Medicine and Infertility, The New York Hospital/Cornell Medical Center, New York, New York 10021, USA.
出版信息
J Assist Reprod Genet. 2003 Dec;20(12):502-5. doi: 10.1023/b:jarg.0000013650.76052.ae.
Abstract
PURPOSE
To examine the roles of Interleukin-1 (IL-1) and IL-1 receptor antagonist (IL-1ra), in in vitro embryo development and subsequent pregnancy outcome.
METHODS
Maternal serum utilized to supplement embryo growth in IVF cycles was analyzed for the presence of IL-1 cytokines.
RESULTS
The maternal serum that was utilized to supplement the embryo media was found to have measurable amounts of IL-1beta and IL-1ra.
CONCLUSIONS
Relative antagonism of the IL-1 system was positively associated with embryo development and pregnancy outcome.
摘要
目的
研究白细胞介素-1（IL-1）和IL-1受体拮抗剂（IL-1ra）在体外胚胎发育及随后妊娠结局中的作用。
方法
分析用于补充体外受精周期中胚胎生长的母体血清中IL-1细胞因子的存在情况。
结果
发现用于补充胚胎培养基的母体血清中含有可测量的IL-1β和IL-1ra。
结论
IL-1系统的相对拮抗作用与胚胎发育和妊娠结局呈正相关。
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