School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Org Lett. 2012 Mar 16;14(6):1405-7. doi: 10.1021/ol3003496. Epub 2012 Mar 8.
An efficient protocol for assembling a polycyclic spiroindoline scaffold is developed, which involves an intramolecular oxidative coupling of dianions derived from indole-embodied β-ketoamides using iodine as the oxidant, and subsequent attack of oxygen anion to the resultant imine moiety. A number of tetracyclic spiroindolines are prepared with moderate to good yields.
开发了一种高效的多环螺吲哚骨架组装方法，该方法涉及使用碘作为氧化剂，对吲哚嵌入的β-酮酰胺衍生的二阴离子进行分子内氧化偶联，然后氧阴离子进攻所得亚胺部分。通过该方法制备了一系列四环螺吲哚啉，产率中等至良好。
