通过钌（II）催化的[3 + 2]环化反应和分子内傅克环化反应一锅法合成多取代螺芴-茚
One-Pot Synthesis of Polysubstituted Spirofluorene-Indene via Ru(II)-Catalyzed [3 + 2] Annulation and Intramolecular Friedel-Crafts Cyclization.
作者信息
Zhu Yu-Qin, Dong Lin
机构信息
Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University , Chengdu 610041, China.
出版信息
J Org Chem. 2015 Oct 16;80(20):9973-9. doi: 10.1021/acs.joc.5b01517. Epub 2015 Oct 7.
PMID:26419666
Abstract
Ru(II)-catalyzed one-pot synthesis of polysubstituted spirofluorene-indenes via [3 + 2] annulation and then intramolecular Friedel-Crafts alkylation has been achieved. The simple method provides a broad scope of aryl ketones and internal alkynes, achieving PAHs skeletons in moderate to good yields.
摘要
通过[3 + 2]环化反应，然后进行分子内傅克烷基化反应，实现了钌（II）催化的一锅法合成多取代螺芴 - 茚。该简单方法适用于多种芳基酮和内炔烃，能以中等至良好的产率得到多环芳烃骨架。
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