Li Xueqin, Xu Jian, Gao Yuzhen, Fang Hua, Tang Guo, Zhao Yufen
Department of Chemistry, College of Chemistry and Chemical Engineering, and Key Laboratory for Chemical Biology of Fujian Province, Xiamen University , Xiamen, Fujian 361005, China.
J Org Chem. 2015 Mar 6;80(5):2621-6. doi: 10.1021/jo502777b. Epub 2015 Feb 16.
The general method for the oxidative cyclization of arylacrylamides with dichloromethane or acetonitrile has been developed. The reactions described provide novel access to chloro- and cyano-containing oxindoles in good to moderate yields that allow the direct formation of a C-C bond and the construction of an oxindole ring in one reaction. The use of a cheap and easily prepared Mn(OAc)3 represents an added advantage of this method.
已开发出用二氯甲烷或乙腈对芳基丙烯酰胺进行氧化环化的通用方法。所述反应提供了以良好至中等产率获得含氯和含氰基的氧化吲哚的新途径，该方法能够在一个反应中直接形成碳-碳键并构建氧化吲哚环。使用廉价且易于制备的醋酸锰（III）是该方法的另一个优点。
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