通过二酮二氧杂环戊酮的芳构化反应仿生全合成苦马豆素 A。
Biomimetic total synthesis of cruentaren A via aromatization of diketodioxinones.
机构信息
Department of Chemistry, Imperial College, London SW7 2AZ, England.
出版信息
J Org Chem. 2012 Apr 6;77(7):3060-70. doi: 10.1021/jo300225z. Epub 2012 Mar 15.
PMID:22401367
Abstract
The total synthesis of cruentaren A, a biologically active resorcylate natural product, is reported. The aromatic unit was constructed via late-stage cyclization and aromatization from a diketodioxinone intermediate and macrocyclization using Fürstner ring-closing alkyne metathesis.
摘要
报道了生物活性的间苯三酚天然产物克鲁伦 A 的全合成。通过二酮二氧杂环己酮中间体的后期环化和芳构化以及使用富斯特纳环 closing 炔烃复分解反应的大环化构建了芳香单元。
Zotero 插件