使用一锅法烯酮生成-捕获-芳构化序列全合成艾氏霉素D。
Total synthesis of aigialomycin D using a one-pot ketene generation-trapping-aromatization sequence.
作者信息
Calo Frederick, Richardson Jeffery, Barrett Anthony G M
机构信息
Department of Chemistry, Imperial College, London SW7 2AZ, England.
出版信息
Org Lett. 2009 Nov 5;11(21):4910-3. doi: 10.1021/ol901979x.
PMID:19799447
Abstract
The total synthesis of aigialomycin D, without the need for phenol protection, was carried out using the C-acylation of a keto-dioxinone dianion, a cascade sequence consisting of ketene generation, alcohol trapping and aromatization, and ring-closing metathesis.
摘要
在无需酚保护的情况下，通过酮二氧杂环己二酮双负离子的C-酰化反应、由乙烯酮生成、醇捕获和芳构化组成的串联反应序列以及关环复分解反应，实现了海葵霉素D的全合成。
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