Calo Frederick, Richardson Jeffery, Barrett Anthony G M
Department of Chemistry, Imperial College, London SW7 2AZ, England.
Org Lett. 2009 Nov 5;11(21):4910-3. doi: 10.1021/ol901979x.
The total synthesis of aigialomycin D, without the need for phenol protection, was carried out using the C-acylation of a keto-dioxinone dianion, a cascade sequence consisting of ketene generation, alcohol trapping and aromatization, and ring-closing metathesis.
在无需酚保护的情况下，通过酮二氧杂环己二酮双负离子的C-酰化反应、由乙烯酮生成、醇捕获和芳构化组成的串联反应序列以及关环复分解反应，实现了海葵霉素D的全合成。
