Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin 150086, China.
Cancer Epidemiol. 2012 Aug;36(4):e201-6. doi: 10.1016/j.canep.2012.02.004. Epub 2012 Mar 7.
studies investigating the associations between UDP-glucuronosyltransferase 1A7 (UGT1A7) gene polymorphisms and various carcinomas risk reported conflicting results. To derive a more precise estimation of the association, we have conducted a meta-analysis.
data were collected from the following electronic databases: PubMed, Medline and Chinese Biomedical Literature Database, with the last report up to September 2011. Case-control studies containing available genotype frequencies of UGT1A7 were chose. The odds ratio (OR) and its 95% confidence interval (95%CI) were used to assess the strength of association.
a total of 22 separate case-control studies including 3852 cases and 5604 controls based on the search criteria were involved in this meta-analysis. The combined results based on all studies showed that there was a statistically significant link between UGT1A73 allele and cancer risk (OR = 1.31, 95%CI = 1.14-1.50, P = 0.0001). In the stratified analysis by racial descent, significant increased risk was found in Asian population for UGT1A73 allele (OR = 1.41, 95%CI = 1.22-1.63, P < 0.00001). No significant associations were found between the UGT1A7 polymorphism and cancer susceptibility among Caucasians and African-Americans. In the subgroup analysis by cancer types, significant associations were found in UGT1A7*2 allele (OR = 1.23, 95%CI = 1.06-1.43, P = 0.006) and *3 allele (OR = 1.51, 95%CI = 1.11-2.06, P = 0.009) for hepatocellular carcinoma, *3 allele for lung cancer (OR = 1.36, 95%CI = 1.11-1.68, P = 0.004) and for bladder cancer (OR = 1.50, 95%CI = 1.09-2.07, P = 0.01).
This meta-analysis suggests that the UGT1A7*3 allele is a risk factor for cancer among Asians, especially for hepatocellular carcinoma.
研究 UDP-葡萄糖醛酸基转移酶 1A7（UGT1A7）基因多态性与各种癌症风险之间的关联的研究报告结果相互矛盾。为了更准确地评估这种关联，我们进行了荟萃分析。
从以下电子数据库中收集数据：PubMed、Medline 和中国生物医学文献数据库，最后报告时间截至 2011 年 9 月。选择包含 UGT1A7 可用基因型频率的病例对照研究。使用比值比（OR）及其 95%置信区间（95%CI）来评估关联的强度。
根据搜索标准，共有 22 项独立的病例对照研究，包括 3852 例病例和 5604 例对照，包含在本次荟萃分析中。基于所有研究的综合结果表明，UGT1A73 等位基因与癌症风险之间存在统计学显著关联（OR = 1.31，95%CI = 1.14-1.50，P = 0.0001）。按种族分类的分层分析显示，亚洲人群 UGT1A73 等位基因的风险显著增加（OR = 1.41，95%CI = 1.22-1.63，P < 0.00001）。在高加索人和非裔美国人中，UGT1A7 多态性与癌症易感性之间没有显著关联。在按癌症类型进行的亚组分析中，在 UGT1A72 等位基因（OR = 1.23，95%CI = 1.06-1.43，P = 0.006）和 UGT1A73 等位基因（OR = 1.51，95%CI = 1.11-2.06，P = 0.009）中发现与肝癌显著相关，UGT1A7*3 等位基因与肺癌（OR = 1.36，95%CI = 1.11-1.68，P = 0.004）和膀胱癌（OR = 1.50，95%CI = 1.09-2.07，P = 0.01）显著相关。
这项荟萃分析表明，UGT1A7*3 等位基因是亚洲人群癌症的危险因素，尤其是肝癌。
