Liu Chuan, Yin Qinghua, Hu Jianbing, Weng Jie, Wang Yajie
Department of Oncology, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, 200433, People's Republic of China,
Tumour Biol. 2014 Feb;35(2):1203-9. doi: 10.1007/s13277-013-1161-9. Epub 2013 Sep 6.
Published data regarding the association between XPG Asp1104His polymorphism and bladder cancer risk remained controversial. This meta-analysis of literatures was performed to draw a more precise estimation of the relationship. We systematically searched PubMed, Embase, and Web of Science with a time limit of June 22, 2013. Summary odds ratios (ORs) with 95 % CIs were used to assess the strength of the association between XPG Asp1104His polymorphism and bladder cancer risk using random effects model. A total of eight case-control studies including 2,613 cases and 2,934 controls were included for analysis. Overall, no significant association was found between XPG Asp1104His polymorphism and bladder cancer susceptibility for CC vs. GG (OR = 1.12, 95 % CI = 0.74-1.69), GC vs. GG (OR = 1.12, 95 % CI = 0.86-1.46), the dominant model CC + GC vs. GG (OR = 1.08, 95 % CI = 0.85-1.38), and the recessive model CC vs. GC + GG (OR = 0.92, 95 % CI = 0.66-1.29). In the subgroup analysis, no significant associations were found in either Asian or non-Asian population. This meta-analysis suggested that XPG Asp1104His polymorphism was not associated with bladder cancer risk.
关于XPG基因Asp1104His多态性与膀胱癌风险之间关联的已发表数据仍存在争议。进行这项文献荟萃分析是为了更精确地评估二者之间的关系。我们在PubMed、Embase和Web of Science数据库中进行了系统检索，检索时间截至2013年6月22日。采用随机效应模型，用汇总比值比（OR）及95%可信区间（CI）评估XPG基因Asp1104His多态性与膀胱癌风险之间关联的强度。总共纳入了8项病例对照研究，包括2613例病例和2934例对照进行分析。总体而言，在CC与GG比较（OR = 1.12，95%CI = 0.74 - 1.69）、GC与GG比较（OR = 1.12，95%CI = 0.86 - 1.46）、显性模型CC + GC与GG比较（OR = 1.08，95%CI = 0.85 - 1.38）以及隐性模型CC与GC + GG比较（OR = 0.92，95%CI = 0.66 - 1.29）中，均未发现XPG基因Asp1104His多态性与膀胱癌易感性之间存在显著关联。在亚组分析中，亚洲人群和非亚洲人群中均未发现显著关联。这项荟萃分析表明，XPG基因Asp1104His多态性与膀胱癌风险无关。
