Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia.
Curr Top Microbiol Immunol. 2012;361:23-38. doi: 10.1007/82_2012_203.
The first complete genome sequence of the P. multocida avian isolate Pm70 was reported in 2001. Analysis of the genome identified many predicted virulence genes, including two encoding homologues of the Bordetella pertussis filamentous haemagluttinins, and genes involved in iron transport and metabolism. Availability of the genome sequence allowed for a range of whole-genome transcriptomic and proteomic analyses and these have helped us understand how P. multocida responds to growth in the presence of antibiotics, under low iron conditions and in the host. Unfortunately, no new P. multocida genome sequences were determined during the rest of the decade, limiting any possible comparative genomic analyses until recently, when several new genome sequences have become available. Here we use the available data to identify a number of important similarities and differences between the strains and determine their phylogenetic relationships. Interestingly, based on the current data there is no clear correlation between phylogenetic relatedness and host predilection or disease.
2001 年，首次报道了禽多杀性巴氏杆菌 Pm70 分离株的全基因组序列。对基因组的分析鉴定了许多预测的毒力基因，包括编码百日咳博德特氏菌丝状血凝素同源物的两个基因，以及参与铁运输和代谢的基因。基因组序列的可用性允许进行一系列全基因组转录组学和蛋白质组学分析，这些分析帮助我们了解多杀性巴氏杆菌如何在存在抗生素的情况下、在低铁条件下以及在宿主中生长。不幸的是，在这十年的其余时间里，没有确定新的多杀性巴氏杆菌基因组序列，直到最近才有几个新的基因组序列可用，这限制了任何可能的比较基因组分析。在这里，我们利用现有数据来确定这些菌株之间的一些重要的相似性和差异，并确定它们的系统发育关系。有趣的是，根据目前的数据，在系统发育关系和宿主倾向或疾病之间没有明显的相关性。
