Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100053, China.
Burrell College of Osteopathic Medicine, Las Cruces, NM 88003, USA.
Oxid Med Cell Longev. 2021 Mar 18;2021:6694566. doi: 10.1155/2021/6694566. eCollection 2021.
Over the past few decades, the immune system, including both the adaptive and innate immune systems, proved to be essential and critical to brain damage and recovery in the pathogenesis of several diseases, opening a new avenue for developing new immunomodulatory therapies and novel treatments for many neurological diseases. However, due to the specificity and structural complexity of the central nervous system (CNS), and the limit of the related technologies, the biology of the immune response in the brain is still poorly understood. Here, we discuss the application of novel technologies in studying the brain immune response, including single-cell RNA analysis, cytometry by time-of-flight, and whole-genome transcriptomic and proteomic analysis. We believe that advancements in technology related to immune research will provide an optimistic future for brain repair.
在过去的几十年中，免疫系统，包括适应性免疫系统和固有免疫系统，被证明在几种疾病的发病机制中对脑损伤和恢复至关重要，为开发许多神经疾病的新型免疫调节疗法和新疗法开辟了新途径。然而，由于中枢神经系统 (CNS) 的特异性和结构复杂性，以及相关技术的限制，大脑中免疫反应的生物学特性仍知之甚少。在这里，我们讨论了新技术在研究大脑免疫反应中的应用，包括单细胞 RNA 分析、飞行时间细胞术以及全基因组转录组和蛋白质组分析。我们相信，与免疫研究相关的技术进步将为大脑修复带来乐观的前景。
