Children's Hospital, University of Helsinki, PO Box 22, FI-00014 Helsinki, Finland.
Diabetologia. 2012 May;55(5):1227-30. doi: 10.1007/s00125-012-2522-4. Epub 2012 Mar 9.
This edition of 'Then and now' discusses the valuable contribution made by Onkamo and colleagues to the field of type 1 diabetes epidemiology in their widely cited paper 'Worldwide increase in incidence of type I diabetes-the analysis of the data on published incidence trends', which was published 13 years ago (Diabetologia 1999;42:1395-1403). At the time, this represented the most extensive analysis of global trends in the epidemiology of type 1 diabetes, and covered/included a considerably larger geographical area than previous studies. The data confirmed that there was a worldwide increase in the incidence of childhood diabetes during the second half of the 20th century. Predictions made by the group for the incidence rates in 2010 pointed to large increases, but in retrospect these turned out to be too conservative, particularly among younger children. Whether the increase in incidence among children aged <15 years has started to level off is unknown. Looking to the future, more data on the epidemiology of type 1 diabetes over the whole lifespan are definitely needed. In addition, descriptive epidemiology needs to be complemented with 'aetiological' epidemiology generating information on the causes of the incidence and prevalence trends.
这一期的“过去与现在”讨论了 Onkamo 及其同事在 13 年前发表的一篇广泛引用的论文《1 型糖尿病流行病学的世界性增长:对已发表发病率趋势数据的分析》中对 1 型糖尿病流行病学领域的贡献。当时,这是对全球 1 型糖尿病发病率趋势的最广泛分析,涵盖的地理区域比以前的研究要大得多。该数据证实,在 20 世纪下半叶,儿童糖尿病的发病率在全球范围内有所上升。该小组对 2010 年发病率的预测指出,发病率将会大幅上升,但回顾过去,这些预测过于保守,尤其是在年幼的儿童中。儿童(<15 岁)发病率的上升是否已经趋于平稳尚不清楚。展望未来,确实需要更多关于整个生命周期内 1 型糖尿病的流行病学数据。此外,描述性流行病学需要辅以“病因学”流行病学,以提供发病率和流行趋势原因的信息。