Department of Otolaryngology, University of Tampere, Medical School, Tampere, Finland.
Int J Nanomedicine. 2012;7:1015-22. doi: 10.2147/IJN.S28185. Epub 2012 Feb 23.
Polymersomes are nanosized vesicles formed from amphiphilic block copolymers, and have been identified as potential drug delivery vehicles to the inner ear. The aim of this study was to provide targeting to specific cells within the inner ear by functionalizing the polymersome surface with Tet1 peptide sequence. Tet1 peptide specifically binds to the trisialoganglioside clostridial toxin receptor on neurons and was expected to target the polymersomes toward the cochlear nerve. The Tet1 functionalized PEG-b-PCL polymersomes were administered using routine drug delivery routes: transtympanic injection and cochleostomy. Delivery via cochleostomy of Tet1 functionalized polymersomes resulted in cochlear nerve targeting; in contrast this was not seen after transtympanic injection.
聚合物囊泡是由两亲性嵌段共聚物形成的纳米囊泡，已被鉴定为内耳潜在的药物传递载体。本研究的目的是通过用 Tet1 肽序列功能化聚合物囊泡表面，为内耳内的特定细胞提供靶向性。Tet1 肽特异性结合神经元上的三唾液酸神经节苷脂克劳氏毒素受体，预计将聚合物囊泡靶向耳蜗神经。Tet1 功能化的 PEG-b-PCL 聚合物囊泡通过常规药物输送途径给药：鼓室注射和圆窗膜切开术。通过圆窗膜切开术递送 Tet1 功能化聚合物囊泡可实现耳蜗神经靶向；相比之下，鼓室注射后则未见这种情况。
