van Wijk Marja J, Hogema Boris M, Maas D Willemijn, Bokhorst Arlinke G
BISLIFE Foundation, Leiden, the Netherlands.
Transfus Med Hemother. 2011 Dec;38(6):357-364. doi: 10.1159/000334599. Epub 2011 Nov 14.
Emerging infectious diseases can compromise the safety of tissues for transplantations. A recent outbreak of Q fever, a zoonosis caused by the bacterium Coxiella burnetii, in the Netherlands compelled the Dutch tissue banks to assess the risk of Q fever transmission through tissue transplantation in order to maintain optimal safety. MATHODS: This article describes the systematic approach that was followed in the Netherlands. This approach included a review of the literature, a qualitative risk assessment, expert opinion gathering and investigations for specific strategies that can help to maintain the balance between tissue safety and availability. RESULTS: This resulted in a specific donor selection policy and in development of further research to fill in gaps in knowledge about Q fever in tissue transplantation. CONCLUSION: The strategy described in this article may be useful for tissue bankers facing similar outbreaks of emerging infections or may be useful for development of future guidelines or assessment strategies for tissue banking.
新发传染病会危及用于移植的组织的安全性。荷兰近期爆发了由伯纳特立克次体细菌引起的人畜共患病——Q热，这促使荷兰组织库评估通过组织移植传播Q热的风险，以确保最佳安全性。
本文描述了荷兰所采用的系统方法。该方法包括文献综述、定性风险评估、专家意见收集以及针对有助于在组织安全性和可用性之间保持平衡的具体策略的调查。
这导致了一项特定的供体选择政策，并开展了进一步研究以填补组织移植中Q热相关知识的空白。
本文所述策略可能对面临类似新发感染疫情的组织库工作人员有用，或者对制定未来组织库指南或评估策略有用。
