Maeta M, Saito H, Katano K, Kondo A, Tsujitani S, Makino M, Ikeguchi M, Kaibara N
First Department of Surgery, Faculty of Medicine, Tottori University, Yonago 683, Japan.
Int J Mol Med. 1998 Jan;1(1):113-6. doi: 10.3892/ijmm.1.1.113.
Activated T lymphocytes release a soluble form of IL-2R (SoIL-2R) into the bloodstream, which can be detected by CD25 monoclonal antibody. Perioperative changes of serum levels of SoIL-2R and the number of CD25-positive cells were monitored simultaneously to clarify the clinical implications of SoIL-2R in patients with gastric cancer (n=91). Preoperative levels of SoIL-2R were significantly higher than in normal controls and levels were a useful indicator of possible lymph node involvement. Postoperative levels of SoIL-2R increased independently of the number of CD25-positive cells. Patients with progressive postoperative increases in levels of SoIL-2R had both a significantly high frequency of postoperative relapse and a poor prognosis. Increased SoIL-2R may reduce the availability of IL-2 by binding to it. Postoperative progressive increases in SoIL-2R appear to be a good indicator for a poor prognosis in patients with gastric cancer.
活化的T淋巴细胞将可溶性白细胞介素-2受体（SoIL-2R）释放到血液中，可通过CD25单克隆抗体检测到。同时监测SoIL-2R血清水平和CD25阳性细胞数量的围手术期变化，以阐明SoIL-2R在胃癌患者（n = 91）中的临床意义。术前SoIL-2R水平显著高于正常对照组，且该水平是可能存在淋巴结受累的有用指标。术后SoIL-2R水平升高与CD25阳性细胞数量无关。术后SoIL-2R水平持续升高的患者术后复发频率显著较高且预后较差。SoIL-2R增加可能通过与白细胞介素-2结合而降低其可用性。术后SoIL-2R持续升高似乎是胃癌患者预后不良的良好指标。
