Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Osaka, Japan.
AJNR Am J Neuroradiol. 2012 Sep;33(8):1458-63. doi: 10.3174/ajnr.A3005. Epub 2012 Mar 8.
CBR imaging is highly susceptible to a PVE produced by morphologic changes in the brain related to aging and brain laterality. We assessed the influence of PVE produced by regional age-related changes in gray matter volume on I-123 iomazenil SPECT and elucidated the age-related changes in human CBR binding by using PVE-corrected SPECT images.
Nineteen right-handed healthy volunteers (range, 25-82 years; mean, 55 ± 21 years) underwent MR imaging and quantitative I-123 iomazenil SPECT imaging. The influence of age-related changes in rGMC on SPECT images before PVE correction was assessed. PVE correction of the SPECT images was performed by using an MR imaging-based method. Voxel-based linear regression analyses of the PVE-corrected SPECT images were performed by using SPM5.
The age-related reductions in rGMC and BP without PVE correction revealed a significant direct proportional correlation. Voxel-based statistical analysis with PVE correction showed no significant age-related changes in BP.
PVE correction was indispensable for the analysis of I-123 iomazenil SPECT images. PVE-corrected quantitative I-123 iomazenil SPECT images revealed no age-related changes in CBR binding in right-handed healthy humans.
CBR 成像对与年龄和大脑偏侧性相关的脑形态变化引起的 PVE 高度敏感。我们评估了由灰质体积的区域年龄相关变化引起的 PVE 对 I-123 iomazenil SPECT 的影响，并通过使用 PVE 校正的 SPECT 图像阐明了人类 CBR 结合的年龄相关变化。
19 名右利手健康志愿者（年龄范围：25-82 岁；平均年龄：55±21 岁）接受了磁共振成像和定量 I-123 iomazenil SPECT 成像。评估了 rGMC 与年龄相关变化对 SPECT 图像在 PVE 校正之前的影响。通过基于 MRI 的方法对 SPECT 图像进行 PVE 校正。使用 SPM5 对 PVE 校正后的 SPECT 图像进行基于体素的线性回归分析。
未进行 PVE 校正时，rGMC 和 BP 与年龄相关的减少呈现出显著的直接比例相关性。进行 PVE 校正的基于体素的统计分析显示 BP 与年龄无显著相关性变化。
对于 I-123 iomazenil SPECT 图像的分析，PVE 校正必不可少。用 PVE 校正的定量 I-123 iomazenil SPECT 图像显示，右利手健康人群的 CBR 结合与年龄无关。
