Xu Chaojin
Departmet of Histology and Embryology, Wenzhou Zhejiang, 325035, PR China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2012 Feb;26(2):186-9.
To review the progress in the treatment of spinal cord injury (SCI) by graft of neural stem cells (NSCs) or bone marrow mesenchymal stem cells (BMSCs) as well as immune characteristics of two stem cells.
Different kinds of documents were widely collected, and then immunologic characteristics of NSCs and BMSCs were summarized. The therapy of SCI by stem cell transplantation was reviewed. Additionally, some problems in treatment were analyzed.
Experimental study showed that graft of NSCs and BMSCs can promote the functional recovery of the injured spinal cord in animals. Due to immunologic properties of two stem cells, rejection reaction of transplantation could produce a harmful effect on SCI treatment.
Transplantation of NSCs or BMSCs might be an effective measure for SCI treatment, but immunologic rejection reaction must be considered.
综述神经干细胞（NSCs）或骨髓间充质干细胞（BMSCs）移植治疗脊髓损伤（SCI）的研究进展以及两种干细胞的免疫特性。
广泛收集各类文献，总结NSCs和BMSCs的免疫特性，综述干细胞移植治疗SCI的情况，并分析治疗中存在的一些问题。
实验研究表明，NSCs和BMSCs移植可促进动物损伤脊髓的功能恢复。由于两种干细胞的免疫特性，移植排斥反应可能对SCI治疗产生有害影响。
NSCs或BMSCs移植可能是治疗SCI的有效措施，但必须考虑免疫排斥反应。
