铜催化苯并恶唑与仲卤代烷的烷基化反应。
Copper-catalyzed alkylation of benzoxazoles with secondary alkyl halides.
机构信息
Laboratory of Inorganic Synthesis and Catalysis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, SB-ISIC-LSCI, BCH 3305, Lausanne 1015, Switzerland.
出版信息
Org Lett. 2012 Apr 6;14(7):1748-51. doi: 10.1021/ol300348w. Epub 2012 Mar 9.
PMID:22404524
Abstract
Copper-catalyzed direct alkylation of benzoxazoles using nonactivated secondary alkyl halides has been developed. The best catalyst is a new copper(I) complex (1), and the reactions are promoted by bis[2-(N,N-dimethylamino)ethyl] ether.
摘要
发展了铜催化的苯并恶唑与非活化的二级卤代烷直接烷基化反应。最佳催化剂是一种新型的铜（I）配合物（1），反应由双[2-（N，N-二甲基氨基）乙基]醚促进。
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