College of Health Sciences, University of Hail, Hail, Saudi Arabia.
J Med Food. 2012 Jun;15(6):576-80. doi: 10.1089/jmf.2011.0266. Epub 2012 Mar 9.
The chemopreventive potential of cardamom was evaluated on 7,12-dimethylbenz[a]anthracene-initiated and croton oil-promoted mouse skin papillomagenesis. A significant reduction in the values of tumor incidence, tumor burden, and tumor yield and the cumulative number of papillomas was observed in mice treated orally with 0.5 mg of cardamom powder in suspension continuously at pre-, peri-, and post-initiational stages of papillomagenesis compared with the control group. The average weight and diameter of tumors recorded were also comparatively lower in the cardamom-treated mouse group. Treatment of cardamom suspension by oral gavage for 15 days resulted in a significant decrease in the lipid peroxidation level of the liver (P < .01). In addition, the reduced glutathione level was significantly elevated in comparison with the control group (P < .05) following cardamom suspension treatment. Taken together, these findings indicate the potential of cardamom as a chemopreventive agent against two-stage skin cancer.
小豆蔻对 7,12-二甲基苯并[a]蒽引发和巴豆油促进的小鼠皮肤乳头状瘤发生的化学预防潜力进行了评估。与对照组相比，在乳头状瘤发生的前、中、后阶段连续口服 0.5mg 小豆蔻粉混悬液的小鼠，其肿瘤发生率、肿瘤负荷、肿瘤产量和乳头状瘤累积数量均显著降低。在小豆蔻处理组的小鼠中，记录的肿瘤平均重量和直径也相对较低。口服小豆蔻混悬液治疗 15 天可显著降低肝脏的脂质过氧化水平（P<.01）。此外，与对照组相比，小豆蔻混悬液处理后还原型谷胱甘肽水平显著升高（P<.05）。综上所述，这些发现表明小豆蔻作为一种化学预防剂对二阶段皮肤癌具有潜在的作用。
