Prashar R, Kumar A, Banerjee S, Rao A R
Department of Zoology, University of Rajasthan, India.
Anticancer Drugs. 1994 Oct;5(5):567-72. doi: 10.1097/00001813-199410000-00008.
We report the chemopreventive property of an ethanolic extract of the leaves of Ocimum sanctum (a traditional medicinal plant) on 7,12-dimethylbenz[a]anthracene induced skin papillomagenesis in male Swiss albino mice. A significant reduction in the values of tumor incidence, average number of tumors per tumor bearing mice and the cumulative number of papillomas was observed in mice treated topically with the leaf extract of O. sanctum at either the peri-initiational, post-initiational stages or continuously at peri- and post-initiational stages of papillomagenesis as compared to the corresponding control group. Topical application of Ocimum leaf extract for 15 days resulted in significant 2-fold elevation of reduced glutathione content in the skin of mice (p < 0.05). Similarly, glutathione S-transferase activity was also observed to be significantly elevated by 25% compared with the control group (p < 0.05) following Ocimum extract treatment.
我们报道了神圣罗勒（一种传统药用植物）叶乙醇提取物对7,12-二甲基苯并[a]蒽诱导的雄性瑞士白化小鼠皮肤乳头状瘤发生的化学预防特性。与相应的对照组相比，在乳头状瘤发生的起始期、起始后期或在起始期和起始后期连续局部用神圣罗勒叶提取物处理的小鼠中，观察到肿瘤发生率、每只荷瘤小鼠的平均肿瘤数和乳头状瘤累积数的值显著降低。局部应用罗勒叶提取物15天导致小鼠皮肤中还原型谷胱甘肽含量显著升高2倍（p<0.05）。同样，与对照组相比，罗勒提取物处理后谷胱甘肽S-转移酶活性也显著升高25%（p<0.05）。
