Duncan B B, Zaimi F, Newman G B, Jenkins J G, Aveling W
Anaesthesia. 1984 May;39(5):426-8. doi: 10.1111/j.1365-2044.1984.tb07309.x.
The effective dose of thiopentone in 90% ( ED90 ) of unpremedicated children is 10.5 mg/kg. This is significantly greater (p less than 0.01) than in premedicated children. The ED90 in children premedicated with TDP (a mixture of trimeprazine , droperidol and physeptone with atropine) is 4.2 mg/kg which is significantly less (p less than 0.05) than with trimeprazine and atropine ( ED90 5.2 mg/kg) or papaveretum and hyoscine ( ED90 5.0 mg/kg).
未用术前药的儿童中，硫喷妥钠的90%有效剂量（ED90）为10.5毫克/千克。这显著高于（p小于0.01）用了术前药的儿童。用TDP（异丙嗪、氟哌利多、苯巴比妥与阿托品的混合物）进行术前用药的儿童的ED90为4.2毫克/千克，这显著低于（p小于0.05）用异丙嗪和阿托品（ED90为5.2毫克/千克）或吗啡和东莨菪碱（ED90为5.0毫克/千克）时的剂量。
