Unit of Virology, Hopital Val de Grace, National Reference Center of Hepatitis E, Paris, France.
J Clin Virol. 2012 Jun;54(2):197-200. doi: 10.1016/j.jcv.2012.02.007. Epub 2012 Mar 10.
Human HEV infections reported in Europe without previous travel to endemic regions are linked to exposure to genotype 3 Hepatitis E virus (HEV).Genotype 3 is widely distributed through human cases and zoonotic reservoir. The geographical distribution of genotype 4 is limited to Asian countries.
The first human case of autochthonous genotype 4 hepatitis E infection was reported in France.
The HEV infection was described in an immunosuppressed patient, presenting an acute myeloblastic leukemia. Investigation of the case was performed on detection of HEV markers in the patient and in the environment.
Hepatitis E infection was diagnosed on the basis of HEV RNA viremia, and detection of anti-HEV IgM. The prognostic of leukemia was favorable and HEV was cleared without relapsing. HEV isolate was classified into genotype 4.
The recent characterization of genotype 4 HEV through swine surveillance in Europe and the description of the first human case in France open interesting questions about the circulation of this genotype: health risks in human population, transmission patterns, and zoonotic reservoir.
在欧洲，没有前往流行地区旅行的情况下报告的人类 HEV 感染与接触基因型 3 型肝炎 E 病毒（HEV）有关。基因型 3 通过人类病例和动物宿主广泛传播。基因型 4 的地理分布仅限于亚洲国家。
法国首次报告了本土基因型 4 型戊型肝炎感染的首例病例。
在一名患有急性髓性白血病的免疫抑制患者中描述了 HEV 感染。对该病例的调查是在患者和环境中检测 HEV 标志物进行的。
根据 HEV RNA 血症和抗 HEV IgM 的检测，诊断为戊型肝炎感染。白血病的预后良好，HEV 无复发清除。HEV 分离株被分类为基因型 4。
最近通过欧洲对猪的监测对基因型 4 HEV 进行的特征描述，以及法国首例人类病例的描述，引发了有关该基因型传播的一些有趣问题：人类种群的健康风险、传播模式和动物宿主。
