Kitaura Satoshi, Wakabayashi Yoshitaka, Okazaki Aiko, Okada Yuta, Okamoto Koh, Ikeda Mahoko, Okugawa Shu, Moriya Kyoji
Department of Infectious Diseases, The University of Tokyo Hospital, Japan.
Department of Internal Medicine, Teikyo University, Japan.
Intern Med. 2020 Jul 1;59(13):1655-1658. doi: 10.2169/internalmedicine.4505-20. Epub 2020 Apr 9.
Hepatitis E virus (HEV) is a common cause of acute hepatitis. Four major genotypes of HEV have been studied, with genotype 4 being the predominant genotype across Asia. We herein describe the case of a 50-year-old man with a history of human immunodeficiency virus (HIV) infection who was admitted with acute transaminitis. Serum anti-HEV-IgA and HEV-RNA were detected at the time of presentation and further testing revealed HEV genotype 4. To the best of our knowledge, this represents the first clinical case report of acute symptomatic HEV genotype 4 infection in an HIV-positive patient in Japan.
戊型肝炎病毒（HEV）是急性肝炎的常见病因。已对HEV的四种主要基因型进行了研究，其中基因型4是亚洲的主要基因型。我们在此描述了一名50岁男性的病例，该患者有人类免疫缺陷病毒（HIV）感染史，因急性转氨酶升高入院。就诊时检测到血清抗HEV-IgA和HEV-RNA，进一步检测显示为HEV基因型4。据我们所知，这是日本首例关于HIV阳性患者急性症状性HEV基因型4感染的临床病例报告。
