Department of Neuropsychiatry, Aichi Medical University, 21 Yazako-Karimata, Nagakute, 480-1195 Aichi, Japan.
Epilepsy Behav. 2012 Apr;23(4):462-5. doi: 10.1016/j.yebeh.2012.01.012. Epub 2012 Mar 9.
Opinions regarding the impact of antiepileptic drugs (AEDs) on the genesis of psychotic symptoms are varied. To re-examine this issue, the records of adult patients with partial epilepsy and newly added AEDs were retrospectively surveyed. The types of newly added AEDs and clinical characteristics were compared between 38 patients with active psychosis and 212 without psychotic history during a follow-up period of 3 to 6 months after initiation of AED administration. Using multivariate logistic regression analysis, the significance of possible predictive variables for development of psychosis was evaluated, which demonstrated that use of zonisamide (ZNS) and phenytoin (PHT), presence of complex partial seizures (CPS), and low intelligence level were significantly correlated with psychosis. We concluded that ZNS and PHT are possible risk factors for development of psychosis along with clinical variables, including the presence of CPS and low intelligence level.
对于抗癫痫药物（AEDs）对精神病症状发生的影响，意见不一。为了重新研究这个问题，我们回顾性调查了患有部分性癫痫的成年患者的记录，并添加了新的 AEDs。在开始使用 AED 治疗后 3 至 6 个月的随访期间，比较了 38 例有活动性精神病和 212 例无精神病病史的患者的新添加 AED 类型和临床特征。采用多变量逻辑回归分析，评估了发生精神病的可能预测变量的意义，结果表明使用佐尼沙胺（ZNS）和苯妥英（PHT）、复杂部分性发作（CPS）和智力低下与精神病显著相关。我们得出结论，ZNS 和 PHT 与包括 CPS 和智力低下在内的临床变量一起，可能是精神病发生的危险因素。
