Dermatology Service, Memorial Sloan-Kettering Cancer Center, New York, New York 10022, USA.
J Am Acad Dermatol. 2012 Nov;67(5):1013-24. doi: 10.1016/j.jaad.2012.02.009. Epub 2012 Mar 9.
Free radicals have long been studied as a contributor to aging and disease processes. Endogenous production of radicals from cellular metabolism and exogenous sources from ultraviolet radiation and pollution can damage the skin on the cellular and tissue levels. Although the body possesses an elegant defense system to prevent radical damage, this innate system can be overwhelmed and lead to a state of oxidative stress or immunosuppression, and can even trigger carcinogenesis. Topical supplementation of antioxidants can provide additional protection to neutralize reactive oxygen species from both endogenous and exogenous sources. This review will discuss our current understanding of the mechanisms of free radical damage and evaluate the potential benefit of topical antioxidants in sunscreens and skin care products.
自由基一直被研究为导致衰老和疾病过程的因素之一。自由基的内源性产生来自细胞代谢，外源性产生来自紫外线辐射和污染，可以在细胞和组织水平上损伤皮肤。尽管身体拥有一个优雅的防御系统来防止自由基损伤，但这个先天系统可能会被压倒，导致氧化应激或免疫抑制状态，甚至可能引发致癌作用。局部补充抗氧化剂可以提供额外的保护，以中和来自内源性和外源性来源的活性氧。这篇综述将讨论我们目前对自由基损伤机制的理解，并评估局部抗氧化剂在防晒霜和护肤品中的潜在益处。
