Biesalski H K, Frank J
Institut für Biologische Chemie und Ernährungswissenschaft, Universität Hohenheim.
Immun Infekt. 1995 Oct;23(5):166-73.
Free radicals and reactive oxygen species can damage cells and tissues of biological organisms. Due to the fact that these compounds are generated continuously in living cells defense mechanisms must exist. This so-called antioxidative system ensures that the formation of free radicals during different physiological processes does not result in cellular damage. Free radicals (oxidants) are produced form the immune system. The purpose of this immune cell products is to destroy invading organisms and damaged tissue. Oxidants enhance IL-1, IL-8 and TNF production in response to inflammatory stimuli. Sophisticated antioxidant defense systems like enzymes or vitamins protect directly and indirectly the host against the damaging influence of oxidants. While endogenous systems can hardly be influenced, exogenous antioxidants, delivered by the diet, can be upregulated in the body. By this way the pro-/antioxidative capacity can be balanced or even unbalanced.
自由基和活性氧会损害生物有机体的细胞和组织。由于这些化合物在活细胞中持续产生，因此必须存在防御机制。这种所谓的抗氧化系统可确保在不同生理过程中自由基的形成不会导致细胞损伤。自由基（氧化剂）由免疫系统产生。这些免疫细胞产物的目的是破坏入侵的生物体和受损组织。氧化剂会响应炎症刺激而增强白细胞介素-1、白细胞介素-8和肿瘤坏死因子的产生。像酶或维生素这样复杂的抗氧化防御系统可直接或间接保护宿主免受氧化剂的损害。虽然内源性系统几乎难以受到影响，但饮食中摄入的外源性抗氧化剂可在体内上调。通过这种方式，促氧化/抗氧化能力可以得到平衡甚至失衡。
