Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Semin Cell Dev Biol. 2012 Jun;23(4):352-61. doi: 10.1016/j.semcdb.2012.02.003. Epub 2012 Mar 8.
Altered cellular metabolism is a defining feature of cancer [1]. The best studied metabolic phenotype of cancer is aerobic glycolysis--also known as the Warburg effect--characterized by increased metabolism of glucose to lactate in the presence of sufficient oxygen. Interest in the Warburg effect has escalated in recent years due to the proven utility of FDG-PET for imaging tumors in cancer patients and growing evidence that mutations in oncogenes and tumor suppressor genes directly impact metabolism. The goals of this review are to provide an organized snapshot of the current understanding of regulatory mechanisms important for Warburg effect and its role in tumor biology. Since several reviews have covered aspects of this topic in recent years, we focus on newest contributions to the field and reference other reviews where appropriate.
细胞代谢改变是癌症的一个显著特征[1]。在癌症中，研究最为广泛的代谢表型是有氧糖酵解，也被称为沃伯格效应，其特征是在氧充足的情况下葡萄糖代谢为乳酸。近年来，由于氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）在癌症患者肿瘤成像中的实际应用，以及越来越多的证据表明癌基因和抑癌基因突变直接影响代谢，人们对沃伯格效应的兴趣日益增加。本综述的目的是提供一个关于沃伯格效应及其在肿瘤生物学中作用的重要调控机制的当前理解的有序快照。由于近年来有几篇综述涵盖了该主题的各个方面，因此我们重点介绍该领域的最新进展，并在适当的地方引用其他综述。
