College of Marine Life Sciences, Ocean University of China, China, Qingdao.
J Biomed Mater Res A. 2012 Jun;100(6):1494-504. doi: 10.1002/jbm.a.33298. Epub 2012 Mar 7.
An in-house built instrument was used to fabricate a small internal diameter (2 mm) artificial vascular prosthesis from biodegradable chitosan. This new artificial vascular prosthesis has shown a good biocompatibility based on the studies of its cell compatibility, inflammatory reaction, and platelet adhesion. In an animal test, the prosthesis was used to replace a 4-cm-long section of femoral artery in each of the seven tested dogs. The patency of the replacement was monitored at regular intervals using Doppler ultrasound diagnostics. Nine months after the implantation, hematoxylin and eosin staining, immunohistochemical study, and scanning electron microscope observation were carried out. Complete decomposition of the prosthesis and replacement by a natural blood vessel were observed. The results suggests that the artificial vascular prosthesis displays many characteristics of the "ideal" small-diameter artificial vascular, and have the biocompatibility that can be tailored to match those desired in vascular replacement application.
采用自行研制的仪器，以可生物降解的壳聚糖为原料制备了小内径（2mm）人工血管假体。基于对其细胞相容性、炎症反应和血小板黏附性的研究，这种新型人工血管假体显示出了良好的生物相容性。在动物实验中，该假体被用于替换 7 只实验犬每只的 4cm 长股动脉段。使用多普勒超声诊断定期监测置换的通畅性。植入后 9 个月，进行苏木精-伊红染色、免疫组织化学研究和扫描电子显微镜观察。观察到假体完全分解并被天然血管替代。结果表明，人工血管假体具有“理想”小直径人工血管的许多特性，并且具有可定制的生物相容性，以满足血管置换应用中的需要。
