College of Marine Life Sciences, Ocean University of China, China, Qingdao.
J Biomed Mater Res A. 2012 Aug;100(8):1938-45. doi: 10.1002/jbm.a.34136. Epub 2012 Apr 10.
Initial clinical feasibility with the small-diameter chitosan artificial vascular prosthesis has been reported previously. Here, we present the results of mechanical properties of artificial vascular prosthesis with 2, 3, and 4 mm inner diameter (ID) and compare some of the properties with the native blood vessel of dog femoral artery. Thickness wall measurement demonstrated the average wall thickness of the artificial vascular prosthesis with 2, 3, and 4 mm ID and the native blood vessel of the dog femoral artery with 3 mm ID were 0.54 ± 0.022 mm, 0.71 ± 0.032 mm, 0.79 ± 0.026 mm, and 0.67 ± 0.22 mm (n = 20). Water absorption rate of 226.02% ± 8.17%, 216.13% ± 4.86%, and 205.69% ± 4.34% were obtained from 2-, 3-, and 4-mm-diameter artificial vascular prosthesis (n = 12), respectively. Water osmotic pressure of the 2-, 3-, and 4-mm-diameter artificial vascular prosthesis was 39.25 ± 3.35 mmHg, 34.2 ± 4.54 mmHg, and 28.00 ± 2.72 mmHg (n = 20), respectively. Water osmotic amount of the 2-, 3-, and 4-cm-diameter artificial vascular prosthesis (n = 20) was 4.90 ± 0.47 mL/(min cm(2) ), 5.51 ± 0.21 mL/(min cm(2) ), and 6.24 ± 0.71 mL/(min cm(2) ), respectively. The ruptured stretching rate of the artificial vascular prosthesis (n = 20) with 2, 3, and 4 mm ID and the native blood vessel was 1.59% ± 0.14%, 1.99% ± 0.24%, 2.52% ± 0.21%, and 32.16% ± 2.15%, respectively. The longitudinal tensile strength of the artificial vascular prosthesis (n = 20) with 2, 3, and 4 mm ID and the native blood vessel was 8.58 ± 1.98 N, 19.75 ± 4.07 N, 22.92 ± 3.85 N, and 18.76 ± 2.05 N, respectively. The suture retention of the artificial vascular prosthesis (n = 20) with 2, 3, and 4 mm ID and the native blood vessel in dry condition is 5.80 ± 0.51 N, 7.01 ± 0.32 N, 8.49 ± 0.56 N, and 7.92 ± 0.39 N, respectively. The suture retention of the artificial vascular prosthesis (n = 20) with 2, 3, and 4 mm ID in wet condition is 3.87 ± 0.43 N, 4.73 ± 0.37 N, 5.63 ± 0.36 N, and 7.92 ± 0.39 N, respectively. The compliance of the artificial vascular prosthesis with 2, 3, and 4 mm ID and the native blood vessel was 6.5% ± 2.6%/100 mmHg, 5.2% ± 1.5%/100 mmHg, 4.7% ± 1.3%/100 mmHg, and 10.3% ± 2.3%/100 mmHg, respectively. The data reported here fulfill the quality requirement of clinical use of this kind of biodegradable small diameter artificial vascular prosthesis.
先前已经报道了小直径壳聚糖人工血管假体的初步临床可行性。在此，我们介绍了具有 2、3 和 4 毫米内径（ID）的人工血管假体的机械性能结果，并将一些性能与狗股动脉的天然血管进行了比较。壁厚测量显示，具有 2、3 和 4mm ID 的人工血管假体和狗股动脉的天然血管的平均壁厚分别为 0.54±0.022mm、0.71±0.032mm、0.79±0.026mm 和 0.67±0.22mm（n=20）。吸水率分别为 226.02%±8.17%、216.13%±4.86%和 205.69%±4.34%（n=12）。2、3 和 4mm 直径人工血管假体的水渗透压分别为 39.25±3.35mmHg、34.2±4.54mmHg 和 28.00±2.72mmHg（n=20）。2、3 和 4cm 直径人工血管假体的水渗透量分别为 4.90±0.47mL/（min·cm2）、5.51±0.21mL/（min·cm2）和 6.24±0.71mL/（min·cm2）（n=20）。人工血管假体（n=20）的破裂拉伸率分别为 1.59%±0.14%、1.99%±0.24%、2.52%±0.21%和 32.16%±2.15%。2、3 和 4mm ID 人工血管假体和天然血管的纵向拉伸强度分别为 8.58±1.98N、19.75±4.07N、22.92±3.85N 和 18.76±2.05N（n=20）。干燥状态下，2、3 和 4mm ID 人工血管假体和天然血管的缝线保持力分别为 5.80±0.51N、7.01±0.32N、8.49±0.56N 和 7.92±0.39N（n=20）。湿态下，2、3 和 4mm ID 人工血管假体的缝线保持力分别为 3.87±0.43N、4.73±0.37N、5.63±0.36N 和 7.92±0.39N（n=20）。人工血管假体的顺应性分别为 6.5%±2.6%/100mmHg、5.2%±1.5%/100mmHg、4.7%±1.3%/100mmHg 和 10.3%±2.3%/100mmHg（n=20）。这里报道的数据满足这种可生物降解小直径人工血管假体临床使用的质量要求。
