University Bordeaux, 33000, Bordeaux, France.
INSERM, Bioingénierie tissulaire, U1026, 33000, Bordeaux, France.
J Cardiovasc Transl Res. 2017 Dec;10(5-6):480-488. doi: 10.1007/s12265-017-9763-z. Epub 2017 Jul 31.
Vascular grafts made of synthetic polymers perform poorly in cardiac and peripheral bypass applications. In these applications, chitosan-based materials can be produced and shaped to provide a novel scaffold for vascular tissue engineering. The goal of this study was to evaluate in vitro the mechanical properties of a novel chitosan formulation to assess its potential for this scaffold. Two chitosan-based hydrogel tubes were produced by modulating chitosan concentration. Based on the standard ISO 7198:1998, the hydrogel tubes were characterized in vitro in terms of suture retention strength, tensile strength, compliance, and burst pressure. By increasing chitosan concentration, suture retention value increased to reach 1.1 N; average burst strength and elastic moduli also increased significantly. The compliance seemed to exhibit a low value for chitosan tubes of high concentration. By modulating chitosan concentration, we produced scaffolds with suitable mechanical properties to be implanted in vivo and withstand physiological blood pressures.
合成聚合物制成的血管移植物在心脏和外周旁路应用中表现不佳。在这些应用中，可以制备壳聚糖基材料并将其成型为用于血管组织工程的新型支架。本研究的目的是评估新型壳聚糖配方的机械性能，以评估其作为支架的潜力。通过调节壳聚糖浓度，制备了两种壳聚糖水凝胶管。根据标准 ISO 7198:1998，从缝线保持强度、拉伸强度、顺应性和爆破压力等方面对水凝胶管进行了体外特性研究。随着壳聚糖浓度的增加，缝线保持值增加到 1.1 N；平均爆破强度和弹性模量也显著增加。高浓度壳聚糖管的顺应性似乎表现出低值。通过调节壳聚糖浓度，我们制备了具有合适机械性能的支架，可以植入体内并承受生理血压。
