水热合成高灵敏度T2加权磁共振成像造影剂：锌掺杂超顺磁性氧化铁纳米晶体

Hydrothermal synthesis of a highly sensitive T2-weigthed MRI contrast agent: zinc-doped superparamagnetic iron oxide nanocrystals.

作者信息

Chen Feng, Bu Wenbo, Lu Chunhua, Chen Gaoxiang, Chen Moying, Shen Xincheng, Liu Rui, Shi Jianlin

机构信息

State Key Laboratory of High performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, People's Republic of China.

出版信息

J Nanosci Nanotechnol. 2011 Dec;11(12):10438-43. doi: 10.1166/jnn.2011.3934.

DOI:10.1166/jnn.2011.3934

PMID:22408922

Abstract

A highly efficient hydrothermal strategy for the synthesis of zinc-doped superparamagnetic iron oxide nanocrystals (SPION:Zn) with lower toxicity and improved sensitivity has been demonstrated. The saturation magnetizations of as-synthesized SPION:Zn were demonstrated to be Zn-dependent and could be tuned from 41.88 emu/g to 79.23 emu/g by changing the amount of Zn. As-synthesized hydrophobic SPION:Zn could be efficiently transferred into water phase through a ultrasonic process with the assistance of cetyltrimethylammonium bromide (CTAB) surfactant. As-obtained CTAB stabilized SPION:Zn was exploited as a MR enhanced contrast agent, and its T2 relaxivity coefficient (r2) was found to be as high as 342.09 mM(-1)s(-1).

摘要

已证明一种高效的水热策略，可用于合成具有较低毒性和更高灵敏度的锌掺杂超顺磁性氧化铁纳米晶体（SPION:Zn）。合成的SPION:Zn的饱和磁化强度被证明与锌有关，并且可以通过改变锌的含量从41.88emu/g调节到79.23emu/g。合成的疏水性SPION:Zn可以在十六烷基三甲基溴化铵（CTAB）表面活性剂的辅助下，通过超声过程有效地转移到水相中。所获得的CTAB稳定的SPION:Zn被用作磁共振增强造影剂，发现其T2弛豫率系数（r2）高达342.09 mM(-1)s(-1)。