Peterson Andrea L, Torres Sheila M F, Rendahl Aaron, Koch Sandra N
Department of Veterinary Clinical Sciences, University of Minnesota, St Paul, MN 55108, USA.
Vet Dermatol. 2012 Jun;23(3):201-e43. doi: 10.1111/j.1365-3164.2012.01044.x. Epub 2012 Mar 12.
Few studies have investigated the frequency of urinary tract infection (UTI) in dogs receiving long-term ciclosporin therapy.
HYPOTHESIS/OBJECTIVES: The goal of the study was to investigate the frequency of UTI in dogs receiving ciclosporin with or without glucocorticoids. A secondary goal was to determine whether bacteriuria, pyuria and urine specific gravity were good predictors of UTI, and if ciclosporin dose, concurrent ketoconazole therapy, sex or duration of therapy affected the frequency of UTI. Animals - Eighty-seven dogs with various inflammatory skin disorders and 59 control dogs with inflammatory skin conditions that had not received glucocorticoids or ciclosporin for 6 months were enrolled.
This study was retrospective. The first urine culture from dogs receiving ciclosporin was compared with control dogs using Fisher's exact test. A logistic mixed model was used to test for association between a positive bacterial culture and duration of treatment, dose of ciclosporin, concurrent ketoconazole therapy and sex. The sensitivities and specificities for bacteriuria, pyuria and urine specific gravity were determined.
Twenty-six of 87 (30%) ciclosporin-treated dogs had at least one positive culture. Compared with 3% positive control samples, 15% were positive in treated dogs (P=0.027). The sensitivity and specificity were, respectively, 64.1 and 98.1% for bacteriuria, 74.4 and 70.9% for pyuria, and 56.4 and 65.3% for urine specific gravity. All other analysed parameters were not significantly different.
The results suggest that routine urine cultures and assessment of bacteriuria by cystocentesis should be part of the monitoring for dogs on long-term ciclosporin with and without glucocorticoids.
很少有研究调查接受长期环孢素治疗的犬只尿路感染（UTI）的发生率。
假设/目的：本研究的目的是调查接受环孢素治疗（无论是否联用糖皮质激素）的犬只UTI的发生率。次要目的是确定菌尿、脓尿和尿比重是否为UTI的良好预测指标，以及环孢素剂量、同时进行的酮康唑治疗、性别或治疗持续时间是否会影响UTI的发生率。动物——87只患有各种炎性皮肤病的犬只以及59只患有炎性皮肤病且6个月内未接受糖皮质激素或环孢素治疗的对照犬只被纳入研究。
本研究为回顾性研究。使用Fisher精确检验比较接受环孢素治疗犬只的首次尿液培养结果与对照犬只的结果。使用逻辑混合模型检验阳性细菌培养结果与治疗持续时间、环孢素剂量、同时进行的酮康唑治疗和性别的相关性。确定菌尿、脓尿和尿比重的敏感性和特异性。
87只接受环孢素治疗的犬只中有26只（30%）至少有一次培养结果呈阳性。与3%的阳性对照样本相比，治疗组犬只中有15%呈阳性（P=0.027）。菌尿的敏感性和特异性分别为64.1%和98.1%，脓尿分别为74.4%和70.9%，尿比重分别为56.4%和65.3%。所有其他分析参数无显著差异。
结果表明，对于接受长期环孢素治疗（无论是否联用糖皮质激素）的犬只，常规尿液培养和通过膀胱穿刺术评估菌尿应作为监测的一部分。
