National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Ocul Immunol Inflamm. 2012 Apr;20(2):104-12. doi: 10.3109/09273948.2011.647228.
To assess the prevalence of hypotony in patients with severe forms of uveitis.
The Multicenter Uveitis Steroid Treatment (MUST) Trial, a randomized study, enrolled 255 patients. Patients with hypotony at the baseline visit were identified.
Twenty (8.3%) of 240 patients with sufficient data had hypotony. Hypotony was more common in patients with uveitis ≥5 years duration (odds ratio [OR] = 5.0; p < .01), and in eyes with a history of ocular surgery (vitrectomy vs. none, OR = 3.1; p = .03). Hypotony was less in patients with older age of uveitis onset (>51 years vs. <51 years, OR = 0.1; p = .02), in Caucasian patients (OR = 0.1; p < .01) compared to African American patients. Hypotonous eyes were more likely to have visual impairment (OR = 22.9; p < .01).
Hypotony is an important complication of uveitis and more commonly affects African-American patients, those with uveitis onset at a younger age, and those with longer disease duration. It is associated with visual impairment.
评估严重葡萄膜炎患者中低眼压的发生率。
多中心葡萄膜炎激素治疗（MUST）试验是一项随机研究，共纳入 255 例患者。对基线检查时出现低眼压的患者进行了识别。
240 例具有足够数据的患者中有 20 例（8.3%）出现低眼压。低眼压在葡萄膜炎持续时间≥5 年的患者中更为常见（比值比[OR] = 5.0；p<.01），并且在有眼部手术史的眼中更为常见（玻璃体切除术与无手术史，OR = 3.1；p =.03）。葡萄膜炎发病年龄较大（>51 岁 vs. <51 岁，OR = 0.1；p =.02）、白种人患者（OR = 0.1；p<.01）的低眼压发生率较低。低眼压眼更有可能出现视力损害（OR = 22.9；p<.01）。
低眼压是葡萄膜炎的一个重要并发症，更常见于非裔美国患者、发病年龄较小的患者和疾病持续时间较长的患者。它与视力损害有关。
