Hanaoka Masachi, Kubo Takahiko, Saitoh Akihiko
Division of Obstetrics, Department of Maternal, Fetal and Neonatal Medicine, National Center for Child Health and Development, Tokyo, Japan.
J Obstet Gynaecol Res. 2012 May;38(5):793-6. doi: 10.1111/j.1447-0756.2011.01786.x. Epub 2012 Mar 13.
The purpose of this study was to examine the seroprevalence of human T-lymphotropic virus (HTLV)-I among pregnant women at our institution in Tokyo, Japan, which is a non-endemic area, and to investigate the results of Western blotting among pregnant women who had obtained positive results from a screening test.
The seroprevalence of HTLV-I was retrospectively reviewed in 11,352 pregnant women who gave birth at the National Center for Child Health and Development in Tokyo, Japan, between 2002 and 2009. For the screening test, a chemiluminescent enzyme immunoassay was performed followed by a confirmatory Western blot test.
The overall positive rate for the screening test was 0.33% (37/11,352). Western blot testing was performed in 36 of these 37 cases. Only nine patients (25%) were positive for HTLV-I by Western blot testing, seven patients (19%) were indeterminate, and 20 patients (56%) were negative.
In this study (carried out in a non-endemic area), the percentage of patients with a positive result from the screening test who were confirmed to be true carriers was significantly low, differing from endemic areas.
本研究旨在调查日本东京我们机构（非流行地区）孕妇中人类嗜T淋巴细胞病毒（HTLV）-I的血清流行率，并调查筛查试验呈阳性的孕妇的蛋白质印迹法检测结果。
回顾性分析了2002年至2009年期间在日本东京国立儿童健康与发展中心分娩的11352名孕妇中HTLV-I的血清流行率。筛查试验采用化学发光酶免疫分析法，随后进行确证性蛋白质印迹试验。
筛查试验的总体阳性率为0.33%（37/11352）。这37例中的36例进行了蛋白质印迹检测。蛋白质印迹检测中只有9例患者（25%）HTLV-I呈阳性，7例患者（19%）结果不确定，20例患者（56%）为阴性。
在本研究（在非流行地区开展）中，筛查试验呈阳性且被确认为真正携带者的患者比例显著较低，这与流行地区不同。
