Yamada Takahiro, Togashi Takehiro, Tsutsumi Hiroyuki, Imamura Masahiro, Okubo Hitoshi, Okabe Mihiro, Takamuro Noriko, Tashiro Kunio, Yano Koichi, Yamamoto Nagafumi, Hirakawa Yukiko, Minakami Hisanori
Department of Obstetrics, Hokkaido University Graduate School of Medicine, N15W7, Kita-ku, Sapporo, 060-8638.
Microbiol Immunol. 2014 Aug;58(8):427-31. doi: 10.1111/1348-0421.12165.
As there is a risk of MTCT of HTLV-1, the HSGP HTLV-1 MTCT was organized in 2011. To determine how many pregnant women are infected with HTLV-1 in Hokkaido, which is the northernmost and the second largest island in Japan with a population of 5,467,000 and 39,392 newborns in 2011, the HSGP HTLV-1 MTCT asked all facilities that may care for pregnant women in Hokkaido in July 2013 to provide information on the number of pregnant women who underwent screening for anti-HTLV-1 antibody using particle agglutination or chemiluminescent enzyme immunoassay, and the numbers of those with positive, equivocal, and negative test results in the screening and confirmation tests using western blotting or PCR methods in 2012, respectively. A total of 111 facilities participated in this study and provided information on 33,617 pregnant women who underwent screening in 2012, corresponding to approximately 85% of all pregnant women who gave birth in Hokkaido in 2012. Of 81 candidates for a confirmation test because of positive (n = 77) or equivocal (n = 4) results on screening, 63 (78%) underwent the confirmation test and, finally, 34 (0.1%) and 33,563 (99.8%) women were judged to be HTLV-1 carriers and non-carriers, respectively. It was concluded that the prevalence rate of HTLV-1 carriers was low, one per 1000 pregnant women in Hokkaido. Approximately 40 infants are born yearly to mothers infected with HTLV-1 in Hokkaido.
由于存在人类嗜T淋巴细胞病毒1型（HTLV-1）母婴传播的风险，2011年开展了HSGP HTLV-1母婴传播项目。为确定在日本最北部且是第二大岛、人口为546.7万且2011年有39392名新生儿的北海道有多少孕妇感染了HTLV-1，HSGP HTLV-1母婴传播项目于2013年7月要求北海道所有可能为孕妇提供护理的机构提供2012年接受颗粒凝集或化学发光酶免疫测定法检测抗HTLV-1抗体的孕妇人数，以及分别采用蛋白质印迹法或聚合酶链反应（PCR）方法进行筛查和确认试验时检测结果为阳性、可疑和阴性的人数。共有111家机构参与了本研究，并提供了2012年接受筛查的33617名孕妇的信息，这大约相当于2012年在北海道分娩的所有孕妇的85%。在筛查结果为阳性（n = 77）或可疑（n = 4）而需进行确认试验的81名孕妇中，63名（78%）接受了确认试验，最终分别有34名（0.1%）和33563名（99.8%）女性被判定为HTLV-1携带者和非携带者。得出的结论是，HTLV-1携带者的患病率较低，在北海道每1000名孕妇中有1名。北海道每年约有40名婴儿出生于感染HTLV-1的母亲。
