趋化因子 SDF1/CXCL12 如何引导不同的细胞到达不同的位置
Attractive guidance: how the chemokine SDF1/CXCL12 guides different cells to different locations.
机构信息
Developmental Genetics Program, Institute of Biomolecular Medicine, New York University, Langone Medical Center, New York, NY 10016, USA.
出版信息
Semin Cell Dev Biol. 2012 May;23(3):333-40. doi: 10.1016/j.semcdb.2012.03.009. Epub 2012 Mar 10.
Abstract
During the development and adult life of multicellular organisms cells move from one location to another as they assemble into organs, seal a wound or fight pathogens. For navigation, migrating cells follow cues that guide them to their final position. Frequently, a single cue simultaneously guides different cells to different positions. Recent studies of one such cue-the chemokine SDF1-suggest strategies for how the animal achieves this task without causing erroneous migration.
摘要
在多细胞生物的发育和成年生活过程中，细胞会从一个位置移动到另一个位置，从而组装成器官、封闭伤口或对抗病原体。为了导航，迁移细胞会跟随引导它们到达最终位置的线索。通常，一个单一的线索会同时引导不同的细胞到达不同的位置。最近对一种这样的线索——趋化因子 SDF1 的研究表明了动物在不引起错误迁移的情况下实现这一任务的策略。
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