Developmental Genetics Program, Institute of Biomolecular Medicine, New York University, Langone Medical Center, New York, NY 10016, USA.
Semin Cell Dev Biol. 2012 May;23(3):333-40. doi: 10.1016/j.semcdb.2012.03.009. Epub 2012 Mar 10.
During the development and adult life of multicellular organisms cells move from one location to another as they assemble into organs, seal a wound or fight pathogens. For navigation, migrating cells follow cues that guide them to their final position. Frequently, a single cue simultaneously guides different cells to different positions. Recent studies of one such cue-the chemokine SDF1-suggest strategies for how the animal achieves this task without causing erroneous migration.
在多细胞生物的发育和成年生活过程中，细胞会从一个位置移动到另一个位置，从而组装成器官、封闭伤口或对抗病原体。为了导航，迁移细胞会跟随引导它们到达最终位置的线索。通常，一个单一的线索会同时引导不同的细胞到达不同的位置。最近对一种这样的线索——趋化因子 SDF1 的研究表明了动物在不引起错误迁移的情况下实现这一任务的策略。
