Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA.
Am J Infect Control. 2012 Dec;40(10):992-6. doi: 10.1016/j.ajic.2011.11.017. Epub 2012 Mar 13.
The anterior naris has been considered the most consistent location of asymptomatic Staphylococcus aureus colonization. However, recent studies have shown that a substantial number of individuals, ranging from 7% to 32% of colonized individuals, are exclusive throat carriers. Most of these studies have been carried out in a health care setting, limiting their generalizability to nonhospitalized populations.
To evaluate anatomic carriage sites of S aureus in individuals outside of a health care setting, we combined the results of 2 cross-sectional studies conducted in Iowa.
S aureus was carried by 103 of 340 individuals (30.3%), including 31 (30.1%) exclusive throat carriers, 44 (42.7%) exclusive nose carriers, and 28 (27.2%) colonized in both sites. Nonwhite race (adjusted odds ratio [OR], 4.91; 95% confidence interval [CI], 1.26-18.3) and younger age (≥30 years: OR, 0.23; 95% CI, 0.10-0.54) were associated with increased odds of exclusive throat carriage, whereas nonwhite race (OR, 5.14; 95% CI, 1.62-16.3) and spring or summer sampling season (OR, 2.62; 95% CI, 1.32-5.18) were associated with increased odds of exclusive nasal carriage.
These findings suggest that including a throat swab in addition to a nasal swab could play an important role in the success of surveillance programs, particularly among younger adults.
前鼻孔被认为是无症状金黄色葡萄球菌定植的最稳定部位。然而，最近的研究表明，大量定植者（7%-32%）为单纯咽部定植者。这些研究大多数是在医疗机构中进行的，限制了其在非住院人群中的推广。
为了评估非医疗机构人群中金黄色葡萄球菌的解剖定植部位，我们结合了在爱荷华州进行的 2 项横断面研究的结果。
340 人中，金黄色葡萄球菌定植于 103 人（30.3%），包括 31 例（30.1%）单纯咽部定植者、44 例（42.7%）单纯鼻部定植者、28 例（27.2%）同时在两个部位定植者。非白色人种（校正比值比[OR]，4.91；95%置信区间[CI]，1.26-18.3）和年龄较大（≥30 岁：OR，0.23；95% CI，0.10-0.54）与单纯咽部定植的几率增加相关，而非白色人种（OR，5.14；95% CI，1.62-16.3）和春季或夏季采样季节（OR，2.62；95% CI，1.32-5.18）与单纯鼻部定植的几率增加相关。
这些发现表明，在监测计划中，除了鼻腔拭子外，还应包括咽拭子，这可能对提高监测成功率具有重要作用，尤其是在年轻成年人中。
