Nakano S, Gillespie H K, Hollister L E
Clin Pharmacol Ther. 1978 Jan;23(1):54-62. doi: 10.1002/cpt197823154.
Volunteer subjects were used to compare a potential antianxiety drug (nabilone, 2-mg single doses) with a standard drug (diazepam, 5-mg single doses). A double-masked design with placebo control was used. Volunteer subjects were selected on the basis of high levels of train anxiety and were tested by two anxiety-inducing procedures--the mirror drawing test and the Stroop color-word test. Anxiety induced by the experimental procedure was alleviated by diazepam and, to a lesser extent, by nabilone. Since doses of the two drugs may not have been equivalent, or the time courses identical, conclusions about their relative efficacy must be guarded. The experimental model is unusual in that antianxiety drugs can be tested in volunteer subjects for true antianxiety effects rather than for side effects, such as cognitive or motor impairment, sleepiness, or other signs of central nervous system depression.
使用志愿者受试者将一种潜在的抗焦虑药物（纳布啡，单剂量2毫克）与一种标准药物（地西泮，单剂量5毫克）进行比较。采用了有安慰剂对照的双盲设计。志愿者受试者是根据高度的训练焦虑水平挑选出来的，并通过两种诱发焦虑的程序进行测试——镜像绘图测试和斯特鲁普颜色-文字测试。实验程序诱发的焦虑通过地西泮得到缓解，纳布啡在较小程度上也有缓解作用。由于两种药物的剂量可能不相等，或者时间进程不一致，因此关于它们相对疗效的结论必须谨慎。该实验模型不同寻常之处在于，抗焦虑药物可以在志愿者受试者身上测试其真正的抗焦虑效果，而不是测试副作用，如认知或运动障碍、嗜睡或中枢神经系统抑制的其他迹象。
