Chekman I S, Simonov P V
Fiziol Zh (1994). 2011;57(6):99-117.
The up-to-date view on a biomembrane structure and functions and the role of lipid, protein and carbohydrate biomembrane components in maintenance of a cell vital activity is summarized in this article. The up-to-date model of a biomembrane structure as a nanocompartmentalized fluid in which lipids and proteins undergo anomalous diffusion is examined. An attention is paid to lipid rafts existence as nanoscaled membrane domains. The analysis of literature and research results concerning the nanonature of ion channels and the mechanism of influence of nanoparticles on a biomembrane is carried out. It is shown that the data on structure and functions ofa biomembrane and the nature of influence of nanoparticles on it is necessary to create new high-performance therapeutic agents, diagnostic tools and to study nanoobjects' toxicological properties.
本文总结了关于生物膜结构与功能以及脂质、蛋白质和碳水化合物生物膜成分在维持细胞生命活动中作用的最新观点。研究了生物膜结构作为脂质和蛋白质进行异常扩散的纳米分隔流体的最新模型。关注脂质筏作为纳米级膜结构域的存在。对有关离子通道的纳米性质以及纳米颗粒对生物膜影响机制的文献和研究结果进行了分析。结果表明，生物膜的结构与功能数据以及纳米颗粒对其影响的性质对于开发新型高性能治疗药物、诊断工具以及研究纳米物体的毒理学特性是必要的。
