Institute for Protein Research, Osaka University, Suita, Japan.
Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi, Japan.
J Membr Biol. 2019 Jun;252(2-3):115-130. doi: 10.1007/s00232-019-00061-w. Epub 2019 Mar 15.
Of all the macromolecular assemblies of life, the least understood is the biomembrane. This is especially true in regard to its atomic structure. Ideas on biomembranes, developed in the last 200 years, culminated in the fluid mosaic model of the membrane. In this essay, I provide a historical outline of how we arrived at our current understanding of biomembranes and the models we use to describe them. A selection of direct experimental findings on the nano-scale structure of biomembranes is taken up to discuss their physical nature, and special emphasis is put on the surprising insights that arise from atomic scale descriptions.
在所有生命的大分子组装体中，最不为人理解的是生物膜。这在其原子结构方面尤其如此。过去 200 年来形成的关于生物膜的概念，最终形成了膜的流动镶嵌模型。在这篇文章中，我提供了一个历史概述，说明我们是如何达到当前对生物膜的理解以及我们用来描述它们的模型的。选择了一些关于生物膜纳米级结构的直接实验结果，以讨论它们的物理性质，并特别强调从原子尺度描述中产生的惊人见解。
