Department of Applied Chemistry, Institute of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan.
J Org Chem. 2012 Apr 6;77(7):3318-24. doi: 10.1021/jo300129m. Epub 2012 Mar 26.
Newly developed ClickFerrophos II ligands were applied in the hydrogenation of α,β-unsaturated phosphonates. The use of a rhodium/ClickFerrophos II catalyst was examined in the hydrogenation of functionalized α,β-unsaturated phosphonates and was revealed to be effective for β-alkyl-β-aryl or β-dialkyl phosphonates, (Z)-β-enolester phosphonates, and α-phenylethenyl phosphonates, producing the corresponding chiral phosphonates in good yields with high enantioselectivities (up to 96% ee).
新开发的 ClickFerrophos II 配体被应用于α,β-不饱和膦酸酯的氢化反应中。在功能化的α,β-不饱和膦酸酯的氢化反应中，考察了铑/ClickFerrophos II 催化剂的应用，结果表明该催化剂对β-烷基-β-芳基或β-二烷基膦酸酯、(Z)-β-烯醇酯膦酸酯和α-苯乙烯基膦酸酯有效，以高对映选择性（高达 96%ee）得到相应的手性膦酸酯。
