Bak B, Jørgensen P H, Andreassen T T
Department of Connective Tissue Biology, University of Aarhus, Denmark.
Clin Orthop Relat Res. 1991 Mar(264):295-301.
The effect of onset and duration of growth hormone administration on the biomechanical properties of healing rat tibial fractures was investigated after 40 days of healing. Biosynthetic human growth hormone, 2.7 mg/kg body weight/day, was given in two daily injections to three groups of rats: (1) for the entire healing period; (2) for the first 20 days; and (3) for the last 20 days of healing. Three corresponding groups of control rats were injected with saline. In Group 1, maximum load and stiffness of the healing fractures increased to 165% and 175%, respectively, compared to the control group. In Group 2, maximum load, stiffness, maximum stress, and energy absorption at maximum load increased to 222%, 175%, 171%, and 247%, respectively, compared to the control group. In Group 3, no statistically detectable effects were found. The results show that growth hormone stimulates fracture healing both when given during the first part of the healing period and when given during the entire healing period.
在骨折愈合40天后，研究了生长激素给药的起始时间和持续时间对大鼠胫骨骨折愈合生物力学特性的影响。将生物合成的人生长激素以2.7毫克/千克体重/天的剂量分两次注射给三组大鼠：（1）在整个愈合期给药；（2）在愈合的前20天给药；（3）在愈合的最后20天给药。三组相应的对照大鼠注射生理盐水。在第1组中，与对照组相比，愈合骨折的最大负荷和刚度分别增加到165%和175%。在第2组中，与对照组相比，最大负荷、刚度、最大应力和最大负荷下的能量吸收分别增加到222%、175%、171%和247%。在第3组中，未发现统计学上可检测到的影响。结果表明，生长激素在愈合期的第一部分给药以及在整个愈合期给药时均能刺激骨折愈合。
