Yoshida T, Shirakusa T, Shigematsu N, Ushijima Y, Inokuchi K
Jpn J Surg. 1979 Sep;9(3):210-7. doi: 10.1007/BF02469423.
This study was done on 110 lung cancer patients who had received surgical resection consisted of two groups; one group of 43 who survived more than 5 years without recurrence and the other group of 67 who died within one year following surgery. Prognostic significance of the histopathological features at the primary tumor site as well as the regional lymph nodes were compared between the two groups. Blood vessel invasion by the tumor and lymph node metastasis appeared to be equally significant prognostic factors. Patients having the both factors had little chance for survival. Abundant lymphoid cell infiltration around the tumor was associated with longer survival. Lymphoid cell infiltration at the site of blood vessel invasion also was associated with better prognosis. Follicular hyperplasia and paracortical hyperplasia in the regional lymph nodes were favorable prognostic indicators, whereas sinus histocytosis was poorly significant prognostic indicator.
本研究对110例接受手术切除的肺癌患者进行，分为两组；一组43例存活超过5年且无复发，另一组67例在术后一年内死亡。比较两组患者原发肿瘤部位及区域淋巴结组织病理学特征的预后意义。肿瘤血管侵犯和淋巴结转移似乎是同等重要的预后因素。同时具有这两个因素的患者生存机会很小。肿瘤周围丰富的淋巴细胞浸润与较长生存期相关。血管侵犯部位的淋巴细胞浸润也与较好的预后相关。区域淋巴结中的滤泡增生和副皮质增生是良好的预后指标，而窦组织细胞增生是意义不大的预后指标。
