Division of Cardiac Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
J Heart Lung Transplant. 2012 Apr;31(4):339-48. doi: 10.1016/j.healun.2012.01.866.
In recent years, ex vivo lung perfusion has emerged as an effective tool for increasing the number of available lungs accepted for transplant. As ex vivo lung perfusion use becomes more widespread, questions have arisen regarding the metabolic activity of the donor lung during ex vivo lung perfusion, optimal perfusion-ventilation strategy, and which parameters best define organ improvement or deterioration. Answers to many of these questions can be found in the published experience with the isolated perfused lung in the study of lung mechanics, pulmonary metabolism, and the effects of various interventions on lung quality. The purpose of this review is to summarize past and present evidence and to provide important background for clinicians and investigators using the ex vivo lung perfusion/isolated perfused lung system.
近年来，体外肺灌注已成为增加可接受移植的肺脏数量的有效工具。随着体外肺灌注的应用越来越广泛，人们对供体肺在体外肺灌注期间的代谢活性、最佳灌注-通气策略以及哪些参数能最好地定义器官改善或恶化产生了疑问。这些问题的许多答案都可以在孤立灌注肺的研究中找到，该研究涉及肺力学、肺代谢以及各种干预措施对肺质量的影响。本文综述的目的是总结过去和现在的证据，并为使用体外肺灌注/离体灌注肺系统的临床医生和研究人员提供重要的背景信息。
