Colombatti A, Dux A, Berns A, Démant P, Hilgers J
J Natl Cancer Inst. 1979 Sep;63(3):869-73. doi: 10.1093/jnci/63.3.869.
Adult B10.Y mice, which are congenic with C57BL/10ScSn ((B10) mice for the H-2 region, expressed a high titer of infectious ecotropic virus in the spleen. F1 hybrids between B10.Y and B10 mice were negative or had very low levels of virus expression. In (B10.Y x B10)F2 segregant mice, the high virus phenotype segregated with the H-2pa haplotype of B10.Y, whereas the virus-negative phenotype was associated with the H-2b haplotype of B10. Molecular hybridization experiments with a selected ecotropic AKR murine leukemia virus cyclic DNA probe indicated that both partner strains possessed ecotropic virus sequences and that the number of sequences present was the same in B10.Y mice as in B10 mice. This finding excluded the possibility that the H-2-related effect might be due to the presence of additional viral structural genes within or close to the H-2 region of B10.Y mice. The level of expression of this endogenous ecotropic virus was therefore affected by regulatory genes of the H-2 region.
成年B10.Y小鼠与C57BL/10ScSn（（B10）小鼠在H-2区域同源），其脾脏中表达高滴度的感染性嗜亲性病毒。B10.Y和B10小鼠之间的F1杂种为阴性或病毒表达水平极低。在（B10.Y×B10）F2分离小鼠中，高病毒表型与B10.Y的H-2pa单倍型分离，而病毒阴性表型与B10的H-2b单倍型相关。用选定的嗜亲性AKR小鼠白血病病毒环状DNA探针进行的分子杂交实验表明，两个亲本菌株都具有嗜亲性病毒序列，并且B10.Y小鼠中存在的序列数量与B10小鼠中的相同。这一发现排除了H-2相关效应可能是由于B10.Y小鼠H-2区域内或附近存在额外病毒结构基因的可能性。因此，这种内源性嗜亲性病毒的表达水平受H-2区域调控基因的影响。
