Melief C J, Louie S, Schwartz R S
J Natl Cancer Inst. 1975 Sep;55(3):691-8. doi: 10.1093/jnci/55.3.691.
The incidence of infectious murine leukemia virus (MuLV) in congenic-resistant C57BL mice was studied. No constant relationship between the incidence of MuLV and the H-2 complex was apparent. Two lines, B10 and B10.A, were examined in detail because the incidence of MuLV in B10 was low and the virus appeared relatively late in life, whereas B10.A animals had a relatively high incidence of infection by MuLV early in life. Further studies of B10.A mice revealed an almost universal concordance between the virologic status of the mother and her offspring. This was particularly evident when (B10 times B10.A)F1 animals were compared with (B10.A times B10)F1 mice: Although genetically identical, the incidence of MuLV in the latter was high, whereas in the former it was low. Transmission of MuLV by milk was proved by foster-nursing experiments; when the infants of MuLV-positive B10.A mothers were suckled on MuLV-negative B10.A mothers, they were free of MuLV. Milk-borne infection may account for the natural dissemination of MuLV among some inbred lines of mice.
对同源抗性C57BL小鼠中传染性小鼠白血病病毒（MuLV）的发病率进行了研究。MuLV的发病率与H-2复合体之间没有明显的恒定关系。对B10和B10.A这两个品系进行了详细检查，因为B10中MuLV的发病率较低，且病毒在生命后期出现，而B10.A动物在生命早期感染MuLV的发病率相对较高。对B10.A小鼠的进一步研究表明，母亲及其后代的病毒学状态几乎完全一致。当比较（B10×B10.A）F1动物与（B10.A×B10）F1小鼠时，这一点尤为明显：尽管基因相同，但后者中MuLV的发病率较高，而前者则较低。通过寄养实验证明了MuLV可通过乳汁传播；当MuLV阳性的B10.A母亲的幼崽由MuLV阴性的B10.A母亲哺乳时，它们没有感染MuLV。乳汁传播感染可能是MuLV在某些近交系小鼠中自然传播的原因。
