Beijing Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, PR China.
Cancer Lett. 2012 Jul 28;320(2):123-9. doi: 10.1016/j.canlet.2012.03.009. Epub 2012 Mar 13.
Protein S-nitrosylation is a covalent post-translational modification through coupling of a nitric oxide (NO) moiety with the reactive thiol group of a protein cysteine residue to form an S-nitrosothiol (SNO). S-nitrosylation is a key mechanism in the transmission of NO-based cellular signals in the vital cellular processes, including transcription regulation, DNA repair, and apoptosis. Contemporary research has implicated dysregulation of S-nitrosylation in severe pathological events, including cancer onset, progression, and treatment resistance. The S-nitrosylation status may be directly linked to many cancer therapy outcomes as well as therapeutic-resistance, emphasizing the need to develop S-nitrosylation-related anti-cancer therapeutics. The role of S-nitrosylated proteins in the development and progression of cancer are varied, generating a critical need for a thorough review of the current dynamic research in this area.
蛋白质 S-亚硝基化是一种通过将一氧化氮（NO）部分与蛋白质半胱氨酸残基的反应性巯基偶联形成 S-亚硝基硫醇（SNO）的共价翻译后修饰。S-亚硝基化是在重要的细胞过程中传递基于 NO 的细胞信号的关键机制，包括转录调节、DNA 修复和细胞凋亡。当代研究表明，S-亚硝基化的失调与严重的病理事件有关，包括癌症的发生、进展和治疗耐药性。S-亚硝基化状态可能与许多癌症治疗结果以及治疗耐药性直接相关，这强调了开发与 S-亚硝基化相关的抗癌治疗方法的必要性。S-亚硝基化蛋白在癌症的发展和进展中的作用多种多样，这就需要对该领域当前的动态研究进行全面的综述。
