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[脑供血不足——银杏叶提取物治疗。60例住院患者双盲研究中的起效时间]

[Cerebral insufficiency--treatment with Ginkgo-biloba extract. Time of onset of effect in a double-blind study with 60 inpatients].

作者信息

Eckmann F

机构信息

Landeskrankenhaus Schleswig.

出版信息

Fortschr Med. 1990 Oct 10;108(29):557-60.

PMID:2242846
Abstract

Sixty inpatients with cerebral insufficiency and the leading symptom depressive mood, were treated in a double-blind study for 6 weeks with a daily dose of 160 mg Ginkgo biloba extract or placebo. After 2, 4 and 6 weeks, changes in 12 typical symptoms in comparison with the last examination, were evaluated. In the group receiving placebo, small, but progressive improvements were observed. In the Ginkgo-biloba group, the overall number of improvements was significantly larger. After 2 weeks the differences were marked for only a few of the symptoms; after 4 and 6 weeks in contrast, in 11 of the 12 symptoms. The largest number of improvements in the Ginkgo-biloba group was observed between the 2nd and 4th weeks of treatment. In this period, about two-thirds of the patients on Ginkgo-biloba, and about one-fifth of the patients on placebo showed improvements.

摘要

60例以抑郁情绪为主要症状的脑供血不足住院患者,在一项双盲研究中接受了为期6周的治疗,每日剂量为160毫克银杏叶提取物或安慰剂。在第2、4和6周时,评估与上次检查相比12种典型症状的变化。在接受安慰剂的组中,观察到虽小但呈渐进性的改善。在银杏叶组中,改善的总数明显更多。2周后,仅少数症状有明显差异;相比之下,在第4和6周时,12种症状中有11种出现差异。银杏叶组在治疗的第2周和第4周之间观察到最大数量的改善。在此期间,约三分之二服用银杏叶的患者和约五分之一服用安慰剂的患者有改善。

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引用本文的文献

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[External validity of clinical trials for treatment of dementia with ginkgo biloba extracts].[银杏叶提取物治疗痴呆症临床试验的外部效度]
Z Gerontol Geriatr. 2008 Aug;41(4):298-312. doi: 10.1007/s00391-008-0521-3. Epub 2008 Mar 11.
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Complementary and alternative medicines in the treatment of dementia: an evidence-based review.补充和替代医学在痴呆治疗中的应用:一项基于证据的综述。
Drugs Aging. 2003;20(13):981-98. doi: 10.2165/00002512-200320130-00003.
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Ginkgo biloba for cerebral insufficiency.银杏叶用于脑供血不足。
Br J Clin Pharmacol. 1992 Oct;34(4):352-8. doi: 10.1111/j.1365-2125.1992.tb05642.x.