Guo S G, Guan S H, Wang G M, Liu G Y, Sun H, Wang B J, Xu F
Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
Department of Anesthesiology, Taian Central Hospital, Taian, China.
J Biol Regul Homeost Agents. 2015 Jan-Mar;29(1):151-7.
This paper aims to compare the curative effects of persimmon leaf extract and ginkgo biloba extract in the treatment of headache and dizziness caused by vertebrobasilar insufficiency. Sixty patients were observed, who underwent therapy with persimmon leaf extract and ginkgo biloba extract based on the treatment of nimodipine and aspirin. After 30 days, 30 patients treated with persimmon leaf extract and 30 patients with ginkgo biloba extract were examined for changes in hemodynamic indexes and symptoms, such as headache and dizziness. The results showed statistically significant differences of 88.3% for the persimmon leaf extract and 73.1% for the ginkgo biloba extract, P < 0.05. Compared to the group of ginkgo biloba extract, the group of persimmon leaf extract had more apparent improvement in the whole blood viscosity, plasma viscosity, fibrinogen, hematokrit, and platelet adhesion rate, and the difference was statistically significant (P < 0.05 or P < 0.01). Based on these analyses, it can be concluded that persimmon leaf extract is better than ginkgo biloba extract in many aspects, such as cerebral circulation improvement, cerebral vascular expansion, hypercoagulable state lowering and vertebrobasilar insufficiency-induced headache and dizziness relief.
本文旨在比较柿叶提取物与银杏叶提取物治疗椎基底动脉供血不足所致头痛、头晕的疗效。观察60例患者，在尼莫地平及阿司匹林治疗基础上，分别给予柿叶提取物及银杏叶提取物治疗。30天后，对30例接受柿叶提取物治疗的患者和30例接受银杏叶提取物治疗的患者进行血流动力学指标及头痛、头晕等症状变化的检查。结果显示，柿叶提取物组有效率为88.3%，银杏叶提取物组为73.1%，差异有统计学意义（P<0.05）。与银杏叶提取物组相比，柿叶提取物组全血黏度、血浆黏度、纤维蛋白原、血细胞比容及血小板黏附率改善更明显，差异有统计学意义（P<0.05或P<0.01）。基于这些分析，可以得出结论，柿叶提取物在改善脑循环、扩张脑血管、降低高凝状态及缓解椎基底动脉供血不足所致头痛、头晕等诸多方面优于银杏叶提取物。
